相关论文: Tumor-immune cell interactions by a fully paraboli…
This paper deals with the solution of following chemotaxis system with competitive kinetics and nonlocal terms \begin{eqnarray*} \left\{ \begin{array}{llll} u_t=d_1\Delta u-\chi_1\nabla\cdot(u\nabla w)+u\left(a_0-a_1u-a_{2}v-a_3\int_\Omega…
This paper investigates the repulsion-consumption system \begin{align}\tag{$\star$} \left\{ \begin{array}{ll} u_t=\Delta u+\nabla \cdot(S(u) \nabla v), \tau v_t=\Delta v-u v, \end{array} \right. \end{align} under no-flux/Dirichlet…
This paper deals with an initial-boundary value problem for a doubly haptotactic cross-diffusion system arising from the oncolytic virotherapy \begin{equation*} \left\{ \begin{array}{lll} u_t=\Delta u-\nabla \cdot(u\nabla v)+\mu…
The chemotaxis system \[ \left\{ \begin{array}{l} u_t = \Delta u - \chi\nabla \cdot (\frac{u}{v}\nabla v), v_t=\Delta v - v+u, \end{array} \right. \] is considered in a bounded domain $\Omega\subset \mathbb{R}^n$ with smooth boundary, where…
We study a Keller-Segel type chemotaxis model with a modified sensitivity function in a bounded domain $\Omega\subset \mathbb{R}^N$, $N\geq2$. The global existence of classical solutions to the fully parabolic system is established provided…
In this paper, we introduce the nonlinear diffusion term $\nabla\cdot(D(u)\nabla u)$ into the chemotaxis-May-Nowak model to investigate the effects of $D(u)$ and chemotaxis on the global existence, boundedness, and finite time blow-up of…
In bounded, spatially two-dimensional domains, the system \begin{equation*} \left\lbrace\begin{alignedat}{3} u_t &= d_1 \Delta u && &&+ u(\lambda_1 - \mu_1 u - a_1 v - a_2 w), \\ v_t &= d_2 \Delta v &&- \xi \nabla \cdot (v \nabla u) &&+…
Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…
There is evidence of synergy between radiotherapy and immunotherapy. Radiotherapy can increase liberation of tumor antigens, causing activation of antitumor T-cells. This effect can be boosted with immunotherapy. Radioimmunotherapy has…
We continue our study of a model for cancer treatment, constructed in Dutta et. al., 2025, by adding Virotherapy to the Chemotherapy and Immunotherapy studied there. It is a dynamical system model for the spread of cancer in healthy tissue.…
Chemotaxis enables cells to systematically approach distant targets that emit a diffusible guiding substance. However, the visual observation of an encounter between a cell and a target does not necessarily indicate the presence of a…
A class of chemotaxis-Stokes systems generalizing the prototype \[\left\{ \begin{array}{rcl} n_t + u\cdot\nabla n &=& \nabla \cdot \big(n^{m-1}\nabla n\big) - \nabla \cdot \big(n\nabla c\big), c_t + u\cdot\nabla c &=& \Delta c-nc, u_t…
We consider a parabolic-elliptic chemotaxis system generalizing \[ \begin{cases}\begin{split} & u_t=\nabla\cdot((u+1)^{m-1}\nabla u)-\nabla \cdot(u(u+1)^{\sigma-1}\nabla v)\\ & 0 = \Delta v - v + u \end{split}\end{cases} \] in bounded…
In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour…
This work presents a new mathematical model to depict the effect of obesity on cancerous tumor growth when chemotherapy as well as immunotherapy have been administered. We consider an optimal control problem to destroy the tumor population…
We study the chemotaxis-Navier-Stokes system \[\left\{\; \begin{aligned} n_t + u\cdot\nabla n &=\Delta n - \nabla\cdot (nS(x,n,c)\nabla c), &&x\in\Omega, t > 0, \\ c_t + u\cdot\nabla c &=\Delta c - n f(c), && x\in \Omega, t > 0, \\ u_t +…
We consider a bilinear optimal control problem associated to the following chemotaxis-consumption model in a bounded domain $\Omega \subset \mathbb{R}^3$ during a time interval $(0,T)$: $$\partial_t u - \Delta u = - \nabla \cdot (u \nabla…
We analyse the Hamiltonian structure of a system of first-order ordinary differential equations used for modeling the interaction of an oncolytic virus with a tumour cell population. The analysis is based on the existence of a Jacobi Last…
A reaction-diffusion model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The…
We consider the following repulsive-productive chemotaxis model: Let $p\in (1,2)$, find $u \geq 0$, the cell density, and $v \geq 0$, the chemical concentration, satisfying \begin{equation}\label{C5:Am} \left\{ \begin{array} [c]{lll}…