相关论文: The effective reproduction number: convexity, conc…
This present results lay the foundations for the study of the optimal allocation of vaccine in the simple epidemiological SIS model where one consider a very general heterogeneous population. In the present setting each individual has a…
We consider the problem of optimal allocation strategies for a (perfect) vaccine in an infinite-metapopulation model (including SIS, SIR, SEIR,. . .), when the loss function is given by the effective reproduction number Re, which is defined…
The basic reproduction number $R_0$ is a fundamental quantity in epidemiological modeling, reflecting the typical number of secondary infections that arise from a single infected individual. While $R_0$ is widely known to scientists,…
As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next…
The basic and effective reproduction numbers are widely used metrics for characterizing the dynamics of infectious disease epidemics. However, the interpretation of these numbers is based on the assumption of homogeneous mixing and may not…
In this study we analyze the evolution of the effective reproduction number, $R$, through a SIR spreading process in heterogeneous networks; Characterizing its decay process allows to analytically study the effects of countermeasures on the…
This paper deals with the problem of estimating variables in nonlinear models for the spread of disease and its application to the COVID-19 epidemic. First unconstrained methods are revisited and they are shown to correspond to the…
We consider the simple epidemiological SIS model for a general heterogeneous population introduced by Lajmanovich and Yorke (1976) in finite dimension, and its infinite dimensional generalization we introduced in previous works. In this…
We rigorously investigate the convergence of a new numerical method, recently proposed by the authors, to approximate the reproduction numbers of a large class of age-structured population models with finite age span. The method consists in…
We consider the bi-objective problem of allocating doses of a (perfect) vaccine to an infinite-dimensional metapopulation in order to minimize simultaneously the vaccination cost and the effective reproduction number $R_e$, which is defined…
We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a bi-objective minimization problem min(C($\eta$),L($\eta$)), where C and L stand…
In this work we study the stability properties of the equilibrium points of deterministic epidemic models with nonconstant population size. Models with nonconstant population have been studied in the past only in particular cases, two of…
For a heterogeneous host population, the basic reproduction number of an infectious disease, $\cR_0$, is defined as the spectral radius of the next generation operator (NGO). The threshold properties of the basic reproduction number are…
This study introduces a novel epidemiological model that expands upon the Kermack-McKendrick model by incorporating the age of infection and reinfection. By including infection age, we can classify participants, which enables a more…
We propose a novel approach to approximate the basic reproduction number $R_0$ as spectral radius of the Next-Generation Operator in time-periodic population models by characterizing the latter via evolution semigroups. Once birth/infection…
We formalize and study the problem of optimal allocation strategies for a (perfect) vaccine in the infinite-dimensional SIS model. The question may be viewed as a bi-objective minimization problem, where one tries to minimize simultaneously…
Network-based epidemic models have been extensively employed to understand the spread of infectious diseases, but have generally overlooked the fact that most realistic networks are dynamical rather than static. In this paper, we study a…
Optimization of vaccine allocations among different segments of a heterogeneous population is important for enhancing the effectiveness of vaccination campaigns in reducing the burden of epidemics. Intuitively, it would seem that…
In this paper we consider epidemic models of directly transmissible SIR (susceptible $\to$ infective $\to$ recovered) and SEIR (with an additional latent class) infections in fully-susceptible populations with a social structure, consisting…
A four dimensional ecoepidemiological model consisting of susceptible prey, infected prey, vaccinated prey and predator is formulated and analyzed in the present work. The functional response is assumed to be of Lotka-Volterra type. We…