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We consider a (degenerate) cross-diffusion model of tumor growth structured by phenotypic trait. We prove the existence of weak solutions and the incompressible limit as the pressure becomes stiff extending methods recently introduced in…

偏微分方程分析 · 数学 2023-04-04 Noemi David

We study a porous medium equation that models tissue growth in a heterogeneous environment. We show that, in the incompressible limit, solutions converge to those of a weak form of a Hele-Shaw type free boundary problem. To obtain enough…

偏微分方程分析 · 数学 2025-12-11 Anthony Sulak , Olga Turanova

A mathematical model for tissue growth is considered. This model describes the dynamics of the density of cells due to pressure forces and proliferation. It is known that such cell population model converges at the incompressible limit…

偏微分方程分析 · 数学 2017-03-01 Sophie Hecht , Nicolas Vauchelet

We analyze a system of cross-diffusion equations that models the growth of an avascular-tumor spheroid. The model incorporates two nonlinear diffusion effects, degeneracy type and super diffusion. We prove the global existence of weak…

偏微分方程分析 · 数学 2022-10-14 Samiha Belmor

Multiphase mechanical models are now commonly used to describe living tissues including tumour growth. The specific model we study here consists of two equations of mixed parabolic and hyperbolic type which extend the standard compressible…

偏微分方程分析 · 数学 2020-01-08 Federica Bubba , Benoît Perthame , Camille Pouchol , Markus Schmidtchen

This paper investigates the incompressible limit of a system modelling the growth of two cells population. The model describes the dynamics of cell densities, driven by pressure exclusion and cell proliferation. It has been shown that…

偏微分方程分析 · 数学 2019-01-08 P. Degond , S. Hecht , N. Vauchelet

Both compressible and incompressible porous medium models are used in the literature to describe the mechanical properties of living tissues. These two classes of models can be related using a stiff pressure law. In the incompressible…

偏微分方程分析 · 数学 2020-06-25 Noemi David , Benoît Perthame

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

偏微分方程分析 · 数学 2021-08-31 Xu'an Dou , Jian-Guo Liu , Zhennan Zhou

We study the incompressible limit of the porous medium equation with a right hand side representing either a source or a sink term, and an injection boundary condition. This model can be seen as a simplified description of non-monotone…

偏微分方程分析 · 数学 2022-01-12 Nestor Guillen , Inwon Kim , Antoine Mellet

This paper proposes a model for the growth two interacting populations of cells that do not mix. The dynamics is driven by pressure and cohesion forces on the one hand and proliferation on the other hand. Following earlier works on the…

细胞行为 · 定量生物学 2018-04-12 Alina Chertock , Pierre Degond , Sophie Hecht , Jean-Paul Vincent

In this study, we analyze the behavior of monotone traveling waves of a one-dimensional porous medium equation modeling mechanical properties of living tissues. We are interested in the asymptotics where the pressure, which governs the…

偏微分方程分析 · 数学 2021-08-25 Anne-Laure Dalibard , Gabriela Lopez-Ruiz , Charlotte Perrin

Nowadays a vast literature is available on the Hele-Shaw or incompressible limit for nonlinear degenerate diffusion equations. This problem has attracted a lot of attention due to its applications to tissue growth and crowd motion modelling…

偏微分方程分析 · 数学 2025-10-29 Noemi David , Alpár R. Mészáros , Filippo Santambrogio

The link between compressible models of tissue growth and the Hele-Shaw free boundary problem of fluid mechanics has recently attracted a lot of attention. In most of these models, only repulsive forces and advection terms are taken into…

偏微分方程分析 · 数学 2023-05-11 Charles Elbar , Benoît Perthame , Andrea Poiatti , Jakub Skrzeczkowski

In this work we study a tissue growth model with applications to tumour growth. The model is based on that of Perthame, Quir\'os, and V\'azquez proposed in 2014 but incorporates the advective effects caused, for instance, by the presence of…

偏微分方程分析 · 数学 2021-03-04 Noemi David , Markus Schmidtchen

We study the "stiff pressure limit" of a nonlinear drift-diffusion equation, where the density is constrained to stay below the maximal value one. The challenge lies in the presence of a drift and the consequent lack of monotonicity in…

偏微分方程分析 · 数学 2017-08-22 Inwon Kim , Norbert Požár , Brent Woodhouse

In this paper, we consider an age-structured mechanical model for tumor growth. This model takes into account the life-cycle of tumor cells by including an age variable. The underlying process for tumor growth is the same as classical tumor…

偏微分方程分析 · 数学 2026-03-05 Maeve Wildes

We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is…

偏微分方程分析 · 数学 2014-01-14 Benoît Perthame , Fernando Quirós , Min Tang , Nicolas Vauchelet

We revisit the problem of proving the incompressible limit for the compressible porous media equation with Newtonian drift and growth. The question is motivated by models of living tissues development including chemotaxis. We extend the…

偏微分方程分析 · 数学 2023-12-29 Qingyou He , Hai-Liang Li , Benoît Perthame

We study a nonlinear, degenerate cross-diffusion model which involves two densities with two different drift velocities. A general framework is introduced based on its gradient flow structure in Wasserstein space to derive a notion of…

偏微分方程分析 · 数学 2018-03-20 Inwon Kim , Alpár R. Mészáros

We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are…

偏微分方程分析 · 数学 2024-03-12 Jiajun Tong , Yuming Paul Zhang
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