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Translation is an important process for prokaryotic and eukaryotic cells to produce necessary proteins for cell growth. Numerious experiments have been performed to explore the translational properties. Diverse models have also been…

生物物理 · 物理学 2015-02-10 Jingwei Li , Yunxin Zhang

We investigate the totally asymmetric simple exclusion process (TASEP) in the presence of obstacles that dynamically bind and unbind from the lattice. The model is motivated by biological processes such as transcription in the presence of…

统计力学 · 物理学 2020-10-21 Juraj Szavits-Nossan , Bartlomiej Waclaw

Inferring unknown initial states in shock-dominated compressible flows from sparse and noisy measurements is a challenging ill-posed inverse problem due to nonlinear wave interactions and limited sensing. In this work, we develop a…

机器学习 · 计算机科学 2026-05-20 Bipin Tiwari , Muhammad Abid , Omer San

We explore and quantify the physical and biochemical mechanisms that may be relevant in the regulation of translation. After elongation and detachment from the 3' termination site of mRNA, parts of the ribosome machinery can diffuse back to…

软凝聚态物质 · 物理学 2009-11-10 Tom Chou

The Totally Asymmetric Simple Exclusion Process (TASEP) is a paradigm of out-of-equilibrium Statistical Physics that serves as a simplistic model for one-way vehicular traffic. Since traffic is perturbed by cars cruising for parking in many…

统计力学 · 物理学 2023-09-25 Valentin Anfray , Alexandre Nicolas

A novel machine learning algorithm is presented, serving as a data-driven turbulence modeling tool for Reynolds Averaged Navier-Stokes (RANS) simulations. This machine learning algorithm, called the Tensor Basis Random Forest (TBRF), is…

流体动力学 · 物理学 2020-04-20 Mikael L. A. Kaandorp , Richard P. Dwight

We address how the interplay between the finite availability and carrying capacity of particles at different parts of a spatially extended system can control the steady state currents and density profiles in the one-dimensional…

统计力学 · 物理学 2024-08-05 Astik Haldar , Parna Roy , Erwin Frey , Abhik Basu

The ribosomal density along the coding region of the mRNA molecule affect various fundamental intracellular phenomena including: protein production rates, organismal fitness, ribosomal drop off, and co-translational protein folding. Thus,…

基因组学 · 定量生物学 2017-05-19 Yoram Zarai , Michael Margaliot , Eduardo D. Sontag , Tamir Tuller

We explore the stationary densities in totally asymmetric exclusion processes (TASEP) with open boundary conditions and spatially inhomogeneous hopping rates. We calculate the steady state density profiles that characterise the associated…

统计力学 · 物理学 2024-10-31 Sudip Mukherjee , Abhik basu

We introduce a new model to study the oscillations of opposite flows sharing a common bottleneck and moving on two Totally Asymmetric Simple Exclusion Process (TASEP) lanes. We provide a theoretical analysis of the phase diagram, valid when…

统计力学 · 物理学 2012-06-15 Asja Jelić , Cécile Appert-Rolland , Ludger Santen

We develop a mean-field theory for the totally asymmetric simple exclusion process (TASEP) with open boundaries, in order to investigate the so-called dynamical transition. The latter phenomenon appears as a singularity in the relaxation…

统计力学 · 物理学 2020-08-11 Davide Botto , Alessandro Pelizzola , Marco Pretti , Marco Zamparo

We consider the one-dimensional totally asymmetric simple exclusion process (TASEP) with position-dependent hopping rates. The problem is solved,in a mean field/adiabatic approximation, for a general (smooth) form of spatial rate variation.…

统计力学 · 物理学 2011-06-15 R. B. Stinchcombe , S. L. A. de Queiroz

Reduced order models (ROMs) play a critical role in fluid mechanics by providing low-cost predictions, making them an attractive tool for engineering applications. However, for ROMs to be widely applicable, they must not only generalise…

机器学习 · 计算机科学 2025-05-06 Ismaël Zighed , Nicolas Thome , Patrick Gallinari , Taraneh Sayadi

We describe the translation invariant stationary states of the one dimensional discrete-time facilitated totally asymmetric simple exclusion process (F-TASEP). In this system a particle at site $j$ in $Z$ jumps, at integer times, to site…

数学物理 · 物理学 2020-06-18 S. Goldstein , J. L. Lebowitz , E. R. Speer

The TASEP is a paradigmatic model from non-equilibrium statistical physics, which describes particles hopping along a lattice of discrete sites. The TASEP is applicable to a broad range of different transport systems, but does not consider…

统计力学 · 物理学 2012-03-20 Chris A. Brackley , Luca Ciandrini , M. Carmen Romano

The totally asymmetric simple exclusion process (TASEP) is a paradigmatic stochastic model for non-equilibrium physics, and has been successfully applied to describe active transport of molecular motors along cytoskeletal filaments.…

生物物理 · 物理学 2018-07-25 Mareike Bojer , Isabella R. Graf , Erwin Frey

The totally asymmetric simple exclusion principle (TASEP) is a fundamental model in nonequilibrium statistical mechanics. It describes the stochastic unidirectional movement of particles along a 1D chain of ordered sites. We consider the…

最优化与控制 · 数学 2025-01-29 Lars Grüne , Kilian Pioch , Thomas Kriecherbauer , Michael Margaliot

We study asymmetric exclusion processes (TASEP) on a nonuniform one-dimensional ring consisting of two segments having unequal hopping rates, or {\em defects}. We allow weak particle nonconservation via Langmuir kinetics (LK), that are…

统计力学 · 物理学 2017-01-12 Bijoy Daga , Souvik Mondal , Anjan Kumar Chandra , Tirthankar Banerjee , Abhik Basu

We revisit the defect-induced nonequilibrium phase transition from a largely homogeneous free-flow phase to a phase-separated congested phase in the sublattice totally asymmetric simple exclusion process (TASEP) with local deterministic…

统计力学 · 物理学 2023-06-27 Gunter M. Schütz

Using the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, exit, and elongation rates along the mRNA strand on the steady state…

基因组学 · 定量生物学 2014-09-19 Gilad Poker , Michael Margaliot , Tamir Tuller