相关论文: On a bi-dimensional chemo-repulsion model with non…
In this paper we consider an optimal control problem arising from a chemotherapeutic drug treatment for tumor cells in a living tissue. The mathematical model for the interaction of chemotherapeutic drug and the normal, tumor and immune…
In this paper, we are concerned with the controllability of a chemotaxis system of parabolic-elliptic type. By linearizing the nonlinear system into two separated linear equations to bypass the obstacle caused by the nonlinear drift term,…
We consider a system of two coupled integro-differential equations modelling populations of healthy and cancer cells under therapy. Both populations are structured by a phenotypic variable, representing their level of resistance to the…
In this work, we will investigate the question of optimal control for bilinear systems with constrained endpoint. The optimal control will be characterized through a set of unconstrained minimization problems that approximate the former.…
This paper deals with the fully parabolic 1d chemotaxis system with diffusion 1/(1 + u). We prove that the above mentioned nonlinearity, despite being a natural candidate, is not critical. It means that for such a diffusion any initial…
Semilinear parabolic systems with bi-linear nonlinearities cover a lot of applications and their optimal control leads to relatively simple optimality conditions. An example is the incompressible Navier-Stokes system for homogeneous fluids,…
This paper presents a mathematical framework for optimizing drug delivery in cancer treatment using a nonlocal model of solid tumor growth. We present a coupled system of partial differential equations that incorporate long-range cellular…
This work deals with a fully parabolic chemotaxis model with nonlinear production and chemoattractant. The problem is formulated on a bounded domain and, depending on a specific interplay between the coefficients associated to such…
In this paper we consider a multidimensional semilinear reaction-diffusion equation and we obtain at any arbitrary time an approximate controllability result between nonnegative states using as control term the reaction coefficient, that is…
We analyze a bilinear control problem governed by a semilinear parabolic equation. The control variable is the Robin coefficient on the boundary. First-order necessary and second-order sufficient optimality conditions are derived. A…
These notes aim to provide a deeper insight on the specifics of two articles dealing with chemotaxis models with nonlinear production. More precisely, we are referring to the papers "Boundedness of solutions to a quasilinear…
In this paper we study the existence of solutions of a parabolic-elliptic system of partial differential equations describing the behaviour of a biological species $u$ and a chemical stimulus $v$ in a bounded and regular domain $\Omega$ of…
We study this zero-flux attraction-repulsion chemotaxis model, with linear and superlinear production $g$ for the chemorepellent and sublinear rate $f$ for the chemoattractant: \begin{equation}\label{problem_abstract} \tag{$\Diamond$}…
In this paper we use a Stackelberg-Nash strategy to show the local null controllability of a parabolic equation where the diffusion coefficient is the product of a degenerate function in space and a nonlocal term. We consider one control…
This paper deals with the analysis of the internal control with constraint of positive kind of a parabolic PDE with nonlinear diffusion when the time horizon is large enough. The minimal controllability time will be strictly positive. We…
This paper aims at providing a first step toward a qualitative theory for a new class of chemotaxis models derived from the celebrated Keller-Segel system, with the main novelty being that diffusion is nonlinear with flux delimiter…
This paper is concerned with a three-component chemotaxis model accounting for indirect signal production,reading as $u_t = \nabla\cdot(\nabla u - u\nabla v)$,$v_t = \Delta v - v + w$ and $0 = \Delta w - w + u$,posed in a ball of $\mathbb…
In this paper we consider quasilinear Keller-Segel type systems of two kinds in higher dimensions. In the case of a nonlinear diffusion system we prove an optimal (with respect to possible nonlinear diffusions generating explosion in finite…
We consider two models which were both designed to describe the movement of eukaryotic cells responding to chemical signals. Besides a common standard parabolic equation for the diffusion of a chemoattractant, like chemokines or growth…
We investigate a distributed optimal control problem for a nonlocal phase field model of viscous Cahn-Hilliard type. The model constitutes a nonlocal version of a model for two-species phase segregation on an atomic lattice under the…