相关论文: On the existence of Hopf bifurcations in the seque…
Phosphorylation networks, representing the mechanisms by which proteins are phosphorylated at one or multiple sites, are ubiquitous in cell signalling and display rich dynamics such as unlimited multistability. Dual-site phosphorylation…
Ordered distributive double phosphorylation is a recurrent motif in intracellular signaling and control. It is either sequential (where the site phosphorylated last is dephosphorylated first) or cyclic (where the site phosphorylated first…
This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephosphorylation network (futile cycle), in which the mechanism for…
We state two sufficient criteria for periodic oscillations in mass action systems. Neither criterion requires a computation of the Hurwitz determinants. Instead, both criteria exploit the linear algebra concepts of $D$-stability and…
Double Hopf bifurcation analysis can be used to reveal some complicated dynamical behavior in a dynamical system, such as the existence or coexistence of periodic orbits, quasi-periodic orbits, or even chaos. In this paper, an algorithm for…
In this paper we analyze a simple mathematical model which describes the interaction between the proteins p53 and Mdm2. For the stationary state we discuss the local stability and the existence of the Hopf bifurcation. Choosing the delay as…
In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model…
Multisite protein phosphorylation plays a pivotal role in regulating cellular signaling and decision-making processes. In this study, we focus on the mathematical underpinnings and informational aspects of sequential, distributive…
We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell…
We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout…
In this paper, we derive the algorithm for calculating the normal form of the double Hopf bifurcation that appears in a memory-based diffusion system via taking memory-based diffusion coefficient and the memory delay as the perturbation…
Multisite phosphorylation networks are encountered in many intracellular processes like signal transduction, cell-cycle control or nuclear signal integration. In this contribution networks describing the phosphorylation and…
This paper presents a general framework to derive the weakly nonlinear stability near a Hopf bifurcation in a special class of multi-scale reaction-diffusion equations. The main focus is on how the linearity and nonlinearity of the fast…
Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…
Propagation of uncertainty in dynamical systems is a significant challenge. Here we focus on random multiscale ordinary differential equation models. In particular, we study Hopf bifurcation in the fast subsystem for random initial…
Multisite phosphorylation plays an important role in intracellular signaling. There has been much recent work aimed at understanding the dynamics of such systems when the phosphorylation/dephosphorylation mechanism is distributive, that is,…
Multisite protein phosphorylation plays a prominent role in intracellular processes like signal transduction, cell-cycle control and nuclear signal integration. Many proteins are phosphorylated in a sequential and distributive way at more…
On a two-dimensional circular domain, we analyze the formation of spatio-temporal patterns for a class of coupled bulk-surface reaction-diffusion models for which a passive diffusion process occurring in the interior bulk domain is linearly…
In this paper, we investigate the dynamical behaviors of a delayed lateral vibration model of footbridges proposed based on the facts that pedestrians will reduce their walking speed or stop walking when the response of the footbridge…
Dual phospho/dephosphorylation cycles, as well as covalent enzymatic-catalyzed modifications of substrates, are widely diffused within cellular systems and are crucial for the control of complex responses such as learning, memory and…