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As whole genomes become widely available, maximum likelihood and Bayesian phylogenetic methods are demonstrating their limits in meeting the escalating computational demands. Conversely, distance-based phylogenetic methods are efficient,…

种群与进化 · 定量生物学 2025-02-07 Matthew J. Penn , Neil Scheidwasser , Mark P. Khurana , Christl A. Donnelly , David A. Duchêne , Samir Bhatt

Historical linguistics aims at inferring the most likely language phylogenetic tree starting from information concerning the evolutionary relatedness of languages. The available information are typically lists of homologous (lexical,…

物理与社会 · 物理学 2015-05-27 Simone Pompei , Vittorio Loreto , Francesca Tria

We propose a novel method for the inference of phylogenetic trees that utilises point configurations on hyperbolic space as its optimisation landscape. Each taxon corresponds to a point of the point configuration, while the evolutionary…

机器学习 · 计算机科学 2021-06-07 Benjamin Wilson

One of the main aims of phylogenetics is the reconstruction of the correct evolutionary tree when data concerning the underlying species set are given. These data typically come in the form of DNA, RNA or protein alignments, which consist…

种群与进化 · 定量生物学 2019-03-22 Mareike Fischer

We consider a method to jointly estimate sparse precision matrices and their underlying graph structures using dependent high-dimensional datasets. We present a penalized maximum likelihood estimator which encourages both sparsity and…

应用统计 · 统计学 2016-08-22 Adria Caballe , Natalia Bochkina , Claus Mayer

We present the first sub-quadratic time algorithm that with high probability correctly reconstructs phylogenetic trees for short sequences generated by a Markov model of evolution. Due to rapid expansion in sequence databases, such very…

种群与进化 · 定量生物学 2012-06-01 Daniel G. Brown , Jakub Truszkowski

When estimating a phylogeny from a multiple sequence alignment, researchers often assume the absence of recombination. However, if recombination is present, then tree estimation and all downstream analyses will be impacted, because…

统计方法学 · 统计学 2014-10-08 Peter B. Chi , Sujay Chattopadhyay , Philippe Lemey , Evgeni V. Sokurenko , Vladimir N. Minin

For some special data in reality, such as the genetic data, adjacent genes may have the similar function. Thus ensuring the smoothness between adjacent genes is highly necessary. But, in this case, the standard lasso penalty just doesn't…

统计方法学 · 统计学 2022-09-29 Xin Xin , Boyi Xie , Yunhai Xiao

We consider the reconciliation problem, in which the task is to find a mapping of a gene tree into a species tree, so as to maximize the likelihood of such fitting, given the available data. We describe a model for the evolution of the…

In epidemiological or demographic studies, with variable age at onset, a typical quantity of interest is the incidence of a disease (for example the cancer incidence). In these studies, the individuals are usually highly heterogeneous in…

统计理论 · 数学 2025-05-20 Vivien Goepp , Jean-Christophe Thalabard , Grégory Nuel , Olivier Bouaziz

Phylogenetic reconstruction aims at finding plausible hypotheses of the evolutionary history of genes or species based on genomic sequence information. The distinction of orthologous genes (genes that having a common ancestry and diverged…

种群与进化 · 定量生物学 2016-02-29 Marc Hellmuth , Nicolas Wieseke

Ancestral sequence reconstruction is a key task in computational biology. It consists in inferring a molecular sequence at an ancestral species of a known phylogeny, given descendant sequences at the tip of the tree. In addition to its many…

种群与进化 · 定量生物学 2022-07-27 Brandon Legried , Sebastien Roch

Regression by composition provides a flexible framework for constructing conditional distributions through sequential group actions. However, when multiple flows act on the same distribution, the model becomes non-identifiable, leading to…

统计方法学 · 统计学 2026-03-30 Safaa K. Kadhem

Fast accumulation of large amounts of complex data has created a need for more sophisticated statistical methodologies to discover interesting patterns and better extract information from these data. The large scale of the data often…

统计方法学 · 统计学 2014-09-09 Yuliya Marchetti , Qing Zhou

In evolutionary biology, genetic sequences carry with them a trace of the underlying tree that describes their evolution from a common ancestral sequence. The question of how many sequence sites are required to recover this evolutionary…

种群与进化 · 定量生物学 2008-06-17 Mareike Fischer , Mike Steel

We consider the problem of estimating species trees from unrooted gene tree topologies in the presence of incomplete lineage sorting, a common phenomenon that creates gene tree heterogeneity in multilocus datasets. One popular class of…

种群与进化 · 定量生物学 2018-12-21 Sebastien Roch

Species tree estimation is a complex problem, due to the fact that different parts of the genome can have different evolutionary histories than the genome itself. One of the causes for this discord is incomplete lineage sorting (also called…

种群与进化 · 定量生物学 2019-04-09 Erin Molloy , Tandy Warnow

We study various types of consistency of honest decision trees and random forests in the regression setting. In contrast to related literature, our proofs are elementary and follow the classical arguments used for smoothing methods. Under…

统计方法学 · 统计学 2026-05-21 Martin Bladt , Rasmus Frigaard Lemvig

Evolution is a process that is influenced by various environmental factors, e.g. the interactions between different species, genes, and biogeographical properties. Hence, it is interesting to study the combined evolutionary history of…

定量方法 · 定量生物学 2013-08-02 Nicolas Wieseke , Matthias Bernt , Martin Middendorf

Mutation rate variation across loci is well known to cause difficulties, notably identifiability issues, in the reconstruction of evolutionary trees from molecular sequences. Here we introduce a new approach for estimating general…

概率论 · 数学 2011-09-30 Elchanan Mossel , Sebastien Roch