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Experiments in recent years have vividly demonstrated that gene expression can be highly stochastic. How protein concentration fluctuations affect the growth rate of a population of cells, is, however, a wide open question. We present a…

分子网络 · 定量生物学 2015-05-13 Sorin Tanase-Nicola , Pieter Rein ten Wolde

In recent years non-demographic variability has been shown to greatly affect dynamics of stochastic populations. For example, non-demographic noise in the form of a bursty reproduction process with an a-priori unknown burst size, or…

种群与进化 · 定量生物学 2018-06-13 Ohad Vilk , Michael Assaf

Establishing a quantitative connection between the population growth rate and the generation times of single cells is a prerequisite for understanding evolutionary dynamics of microbes. However, existing theories fail to account for the…

种群与进化 · 定量生物学 2017-09-19 Jie Lin , Ariel Amir

This paper investigates the dynamics of biomass in a marine ecosystem. A stochastic process is defined in which organisms undergo jumps in body size as they catch and eat smaller organisms. Using a systematic expansion of the master…

种群与进化 · 定量生物学 2010-01-11 Samik Datta , Gustav W. Delius , Richard Law

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

概率论 · 数学 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard

We review and extend results for mutation, selection, genetic drift, and migration in a one-dimensional continuous population. The population is described by a continuous limit of the stepping stone model, which leads to the stochastic…

种群与进化 · 定量生物学 2011-04-14 K. S. Korolev , Mikkel Avlund , Oskar Hallatschek , David R. Nelson

We show that a simple nonlinear differential equation (originally studied in the physics of disordered systems) is able to mathematically describe the global population growth over the past 12000 years. Different regimes of population…

种群与进化 · 定量生物学 2026-05-27 Alessio Zaccone , Kostya Trachenko

We analyse a stochastic SIS epidemic amongst a finite population partitioned into households. Since the population is finite, the epidemic will eventually go extinct, i.e., have no more infectives in the population. We study the effects of…

种群与进化 · 定量生物学 2009-08-05 Tom Britton , Peter Neal

This paper considers adiabatic reduction in both discrete and continuous models of stochastic gene expression. In gene expression models, the concept of bursting is a production of several molecules simultaneously and is generally…

概率论 · 数学 2013-01-08 Romain Yvinec

We consider a stochastic individual-based model of adaptive dynamics for an asexually reproducing population with mutation, with linear birth and death rates, as well as a density-dependent competition. To depict repeating changes of the…

种群与进化 · 定量生物学 2025-05-28 Manuel Esser , Anna Kraut

Populations of competing biological species exhibit a fascinating interplay between the nonlinear dynamics of evolutionary selection forces and random fluctuations arising from the stochastic nature of the interactions. The processes…

种群与进化 · 定量生物学 2012-05-08 A. Dobrinevski , E. Frey

The present paper is devoted to the study of the long term dynamics of diffusion processes modelling a single species that experiences both demographic and environmental stochasticity. In our setting, the long term dynamics of the diffusion…

概率论 · 数学 2024-07-10 Alexandru Hening , Weiwei Qi , Zhongwei Shen , Yingfei Yi

Many of the existing stochastic models of gene expression contain the first-order decay reaction term that may describe active protein degradation or dilution. If the model variable is interpreted as the molecule number, and not…

生物物理 · 物理学 2019-05-22 Jakub Jędrak , Maciej Kwiatkowski , Anna Ochab-Marcinek

The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathematical techniques allow us to generate knowledge regarding individual behaviour, which can be analysed to…

种群与进化 · 定量生物学 2021-04-28 Stuart T. Johnston , Matthew J. Simpson , Edmund J. Crampin

Coalescent theory combined with statistical modeling allows us to estimate effective population size fluctuations from molecular sequences of individuals sampled from a population of interest. When sequences are sampled serially through…

种群与进化 · 定量生物学 2021-11-02 Michael D. Karcher , Marc A. Suchard , Gytis Dudas , Vladimir N. Minin

Traditionally, frequency dependent evolutionary dynamics is described by deterministic replicator dynamics assuming implicitly infinite population sizes. Only recently have stochastic processes been introduced to study evolutionary dynamics…

统计力学 · 物理学 2007-05-23 Arne Traulsen , Jens Christian Claussen , Christoph Hauert

Growth-fragmentation processes model systems of cells that grow continuously over time and then fragment into smaller pieces. Typically, on average, the number of cells in the system exhibits asynchronous exponential growth and, upon…

概率论 · 数学 2023-06-08 Emma Horton , Alexander R. Watson

Mutation-induced drug resistance in cancer often causes the failure of therapies and cancer recurrence, despite an initial tumor reduction. The timing of such cancer recurrence is governed by a balance between several factors such as…

概率论 · 数学 2013-07-22 Jasmine Foo , Kevin Leder

We study simple stochastic scenarios, based on birth-and-death Markovian processes, that describe populations with Allee effect, to account for the role of demographic stochasticity. In the mean-field deterministic limit we recover…

We model the growth of a cell population by a piecewise deterministic Markov branching tree. Each cell splits into two offsprings at a division rate $B(x)$ that depends on its size $x$. The size of each cell grows exponentially in time, at…

概率论 · 数学 2015-05-29 Marie Doumic , Marc Hoffmann , Nathalie Krell , Lydia Robert