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We develop an efficient and reliable adaptive finite element method (AFEM) for the nonlinear Poisson-Boltzmann equation (PBE). We first examine the regularization technique of Chen, Holst, and Xu; this technique made possible the first a…

数值分析 · 数学 2010-10-01 Michael Holst , James Andrew McCammon , Zeyun Yu , Yongcheng Zhou , Yunrong Zhu

The Poisson-Boltzmann equation is widely used to model molecular electrostatics; however, it is usually solved in linearised form because the sinh nonlinearity is challenging, limiting its applicability in highly charged systems such as…

计算物理 · 物理学 2026-04-20 Mauricio Guerrero-Montero , Michal Bosy , Christopher D. Cooper

In this article we study adaptive finite element methods (AFEM) with inexact solvers for a class of semilinear elliptic interface problems. We are particularly interested in nonlinear problems with discontinuous diffusion coefficients, such…

数值分析 · 数学 2016-08-24 Michael Holst , Ryan Szypowski , Yunrong Zhu

The Poisson-Boltzmann equation is a widely used model to study the electrostatics in molecular solvation. Its numerical solution using a boundary integral formulation requires a mesh on the molecular surface only, yielding accurate…

数值分析 · 数学 2020-09-25 Vicente Ramm , Jehanzeb H. Chaudhry , Christopher D. Cooper

The Poisson--Boltzmann equation is widely used to model electrostatics in molecular systems. Available software packages solve it using finite difference, finite element, and boundary element methods, where the latter is attractive due to…

计算物理 · 物理学 2025-12-24 Michal Bosy , Matthew W. Scroggs , Timo Betcke , Erik Burman , Christopher D. Cooper

In this paper, we develop an adaptive finite element method for the nonlinear steady-state Poisson-Nernst-Planck equations, where the spatial adaptivity for geometrical singularities and boundary layer effects are mainly considered. As a…

数值分析 · 数学 2020-08-21 Tingting Hao , Manman Ma , Xuejun Xu

The Poisson-Boltzmann equation is a nonlinear elliptic equation with Dirac distribution sources, which has been widely applied to the prediction of electrostatics potential of biological biomolecular systems in solution. In this paper, we…

数值分析 · 数学 2023-07-18 Linghan Huang , Shi Shu , Ying Yang

We consider a class of nonlinear elliptic problems associated with models in biophysics, which are described by the Poisson-Boltzmann equation (PBE). We prove mathematical correctness of the problem, study a suitable class of…

数值分析 · 数学 2020-12-15 Johannes Kraus , Svetoslav Nakov , Sergey Repin

In this paper we have derived explicitly computable bounds on the error in energy norms for the fully nonlinear Poisson-Boltzmann equation. Together with the computable bounds, we have also obtained efficient error indicators which can…

数值分析 · 数学 2018-05-30 Johannes Kraus , Svetoslav Nakov , Sergey Repin

In numerical simulations of many charged systems at the micro/nano scale, a common theme is the repeated solution of the Poisson-Boltzmann equation. This task proves challenging, if not entirely infeasible, largely due to the nonlinearity…

数值分析 · 数学 2018-08-29 Lijie Ji , Yanlai Chen , Zhenli Xu

The Poisson-Boltzmann equation (PBE) is an implicit solvent continuum model for calculating the electrostatic potential and energies of ionic solvated biomolecules. However, its numerical solution remains a significant challenge due strong…

We describe a three-stage procedure to analyze the dependence of Poisson Boltzmann calculations on the shape, size and geometry of the boundary between solute and solvent. Our study is carried out within the boundary element formalism, but…

生物物理 · 物理学 2007-11-27 P. Kar , Y. Wei , U. H. E. Hansmann , S. Hoefinger

The Poisson-Boltzmann equation offers an efficient way to study electrostatics in molecular settings. Its numerical solution with the boundary element method is widely used, as the complicated molecular surface is accurately represented by…

数值分析 · 数学 2021-08-25 Stefan D. Search , Christopher D. Cooper , Elwin van't Wout

We consider the nonlinear Poisson-Boltzmann equation in the context of electrostatic models for a biological macromolecule, embedded in a bounded domain containing a solution of an arbitrary number of ionic species which is not necessarily…

偏微分方程分析 · 数学 2022-04-26 José A. Iglesias , Svetoslav Nakov

The non-linear Poisson-Boltzmann equation for a circular, uniformly charged platelet, confined together with co- and counter-ions to a cylindrical cell, is solved semi-analytically by transforming it into an integral equation and solving…

软凝聚态物质 · 物理学 2009-10-31 R. J. F. Leote de Carvalho , E. Trizac , J. P Hansen

We present the theory and implementation of a Poisson-Boltzmann implicit solvation model for electrolyte solutions. This model can be combined with arbitrary electronic structure methods that provide an accurate charge density of the…

计算物理 · 物理学 2020-01-08 Christopher J. Stein , John M. Herbert , Martin Head-Gordon

In this paper, we study a priori error estimates for the finite element approximation of the nonlinear Schr\"{o}dinger-Poisson model. The electron density is defined by an infinite series over all eigenvalues of the Hamiltonian operator. To…

数值分析 · 数学 2023-07-20 Tao Cui , Wenhao Lu , Naiyan Pan , Weiying Zheng

We consider the Poisson-Boltzmann equation in a periodic cell, representative of a porous medium. It is a model for the electrostatic distribution of $N$ chemical species diluted in a liquid at rest, occupying the pore space with charged…

偏微分方程分析 · 数学 2015-04-24 Gregoire Allaire , Jean-Francois Dufreche , Andro Mikelic , Andrey Piatnitski

The Poisson-Boltzmann equation (PBE) models the electrostatic interactions of charged bodies such as molecules and proteins in an electrolyte solvent. The PBE is a challenging equation to solve numerically due to the presence of…

数值分析 · 数学 2018-07-17 Jehanzeb H. Chaudhry

We investigate mathematically a nonlinear approximation type approach recently introduced in [A. Ammar et al., J. Non-Newtonian Fluid Mech., 2006] to solve high dimensional partial differential equations. We show the link between the…

数值分析 · 数学 2008-11-05 C. Le Bris , T. Lelievre , Y. Maday
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