医学物理
Radiotherapy treatment planning remains a time-intensive iterative process requiring expert intervention in commercial treatment planning system (TPS). While machine learning approaches have demonstrated promise, most remain depedent on…
Cerebral hemodynamics is fundamentally regulated by the Circle of Willis (CoW), which redistributes flow through communicating arteries to stabilize perfusion under anatomical variations and vascular stenosis. In this study, we develop a…
Spin-Exchange Relaxation-Free Optically Pumped Magnetometers (SERF-OPMs) are increasingly used in multichannel biomagnetic sensing, yet their timing performance remains poorly characterized. This contribution presents the first…
The choice of lung protective ventilation settings for mechanical ventilation has a considerable impact on patient outcome, yet identifying optimal ventilatory settings for individual patients remains highly challenging due to the inherent…
As global population aging intensifies, there is growing interest in the study of biological age. Bones have long been used to evaluate biological age, and the decline in bone density with age is a well-recognized phenomenon in adults.…
A pulse oximeter is an optical device that monitors tissue oxygenation levels. Traditionally, these devices estimate the oxygenation level by measuring the intensity of the transmitted light through the tissue and are embedded into everyday…
Objective Interaction vertex imaging (IVI) is used for range monitoring in carbon ion radiotherapy, detecting depth differences between Bragg peak positions. Online range monitoring, which provides feedback during beam delivery, is…
Interaction Vertex Imaging (IVI) is used for range monitoring (RM) in carbon ion radiotherapy. The purpose of RM is to measure the Bragg peak (BP) position for each contributing beam, and detect any changes. Currently, there is no consensus…
The development of PET and positronium imaging techniques is strictly related to the availability of suitable radionuclides and robust radiochemistry platforms. Among the emerging candidates, $^{44}$Sc has attracted significant interest due…
Accelerated charged particles offer significant physical advantages over X-rays in radiotherapy. In addition to their superior depth-dose distribution, heavy ions provide notable biological benefits compared to protons. Specifically, at…
Purpose To evaluate the reasoning capabilities of large language models (LLMs) in performing root cause analysis (RCA) of radiation oncology incidents using narrative reports from the Radiation Oncology Incident Learning System (RO-ILS),…
The electrocardiogram (ECG) is modulated by torso-heart anatomy, and this challenges patients' diagnosis and risk stratification. This study aims to quantify how torso-heart anatomical factors affect sex-differences in ECG biomarkers in…
Magnetic Particle Imaging (MPI) is a promising imaging modality that tracks magnetic nanoparticles (MNPs) to generate real time, high-resolution images. However, achieving an optimal balance between strong signal strength and sharp image…
In this study, we develop vector flow imaging techniques for multi-layered models with a high wavespeed contrast using photoacoustic and ultrasonic imaging. We use refraction-corrected delay-and-sum image reconstruction (RC-DAS), which…
We present a new approach for retrieving dark-field, phase shift, and attenuation images from speckle-based X-ray imaging data. Speckle-based X-ray imaging (SBXI) exploits sample-induced alterations to a reference near-field speckle pattern…
The purpose of this study is to enable in-vivo three-dimensional (3-D) ultrasound localization microscopy (ULM) of posterior ocular microvasculature using a 256-channel system and a 1024-element matrix array, and to overcome limitations of…
Background: Recently, mixed carbon-helium beams were proposed for range verification in carbon ion therapy: Helium, with three times the range of carbon, serves as an on-line range probe, and is mixed into a therapeutic carbon beam.…
Purpose: To develop DarkSPARC, a retrospective, training-free, self-calibrated spectral reconstruction method that converts routine bright-blood 3D left atrial (LA) late gadolinium enhancement (LGE) MRI into a dark-blood image, and to…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
Objective: In this work, we propose a framework for differentiable forward and back-projector that enables scalable, accurate, and memory-efficient gradient computation for rigid motion estimation tasks. Methods: Unlike existing approaches…