医学物理
The Gaussian phase approximation (GPA) underlies many standard diffusion magnetic resonance (MR) signal models, yet its validity is rarely scrutinized. Here, we assess the validity of the GPA by analytically deriving the excess phase…
Dynamic positron emission tomography (PET) reconstruction often presents high noise due to the use of short duration frames to describe the kinetics of the radiotracer. Here we introduce a new method to calculate a kernel matrix to be used…
Early cancer detection relies on invasive tissue biopsies or liquid biopsies limited by biomarker dilution. In contrast, tumour-derived extracellular vesicles (EVs) carrying biomarkers like melanoma-associated antigen-A (MAGE-A) are highly…
Bone marrow (BM) metabolic quantification with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is of broad clinical significance for accurate assessment of BM at staging and follow-up, especially when immunotherapy is…
Due to the prolonged MRI encoding process, respiratory motion can cause undesired artifacts and image blurring, degrading image quality and limiting clinical applications in abdominal and pulmonary imaging. In this work, we develop a…
Emerging concepts of metamaterials for MRI offer improved image quality through enhanced RF field control. However, current designs are often limited by bulky configurations, dielectric losses, and limited adaptability. Patient-specific…
Organoids are three-dimensional (3D) in vitro models for studying tissue development, disease progression, and physiological responses. Holotomography (HT) enables long-term, label-free imaging of live organoids by reconstructing volumetric…
Background: Mechanical Thrombectomy (MT) is a widely accepted first-line treatment for Acute Ischemic Stroke (AIS) and it has been studied using in vitro and in silico models. Thrombectomy outcomes have been performed for patient-specific…
Multiple clinical trials have demonstrated the superiority of mechanical thrombectomy (MT) in treating acute ischemic stroke (AIS). Stent retriever (SR) and aspiration techniques are the standard methods for removing occluded emboli, with…
Positron range (PR) blurring degrades positron emission tomography (PET) image resolution, particularly for high-energy emitters like gallium-68 (68 Ga). We introduce Dual-Input Dynamic Convolution (DDConv), a novel computationally…
Computational point-of-care (POC) sensors enable rapid, low-cost, and accessible diagnostics in emergency, remote and resource-limited areas that lack access to centralized medical facilities. These systems can utilize neural network-based…
Cone Beam CT (CBCT) is an important imaging modality nowadays, however lower image quality of CBCT compared to more conventional Computed Tomography (CT) remains a limiting factor in CBCT applications. Deep learning reconstruction methods…
Porous ceramic microspheres are a desirable substance for bone tissue reconstruction and delivery applications. This study focuses on Mg-Ca silicate microspheres encapsulated in biodegradable poly (lactic-co-glycolic acid) (PLGA) to serve…
Personalized cardiac diagnostics require accurate reconstruction of myocardial displacement fields from sparse clinical imaging data, yet current methods often demand intrusive access to computational models. In this work, we apply the…
Traditional approaches for molecular imaging of Parkinson's disease (PD) in vivo require radioactive isotopes, lengthy scan times, or deliver only low spatial resolution. Recent advances in saturation transfer-based PD magnetic resonance…
Reducing the scanning time of very-low field (VLF) magnetic resonance imaging (MRI) scanners, commonly employed for stroke diagnosis, can enhance patient comfort and operational efficiency. The conventional parallel imaging (PI) technique…
Magnetic resonance imaging (MRI) relies on radiofrequency (RF) excitation of proton spin. Clinical diagnosis requires a comprehensive collation of biophysical data via multiple MRI contrasts, acquired using a series of RF sequences that…
Laser powder bed fusion (L-PBF) of semi-crystalline polymers such as polyamide-12 (PA12) has found increasing use in various industrial applications. However, achieving high dimensional accuracy remains a significant challenge. Despite the…
This article develops a unified variational framework for configurational (or material) forces in both Classical (3D, non-relativistic) and Relativistic (4D) Continuum Mechanics. Configurational forces describe the evolution of material…
Addressing a critical challenge in current tissue-engineering practices, this study aims to enhance vascularization in 3D porous scaffolds by incorporating bioceramics laden with pro-angiogenic ions. Specifically, freeze-dried gelatin-based…