医学物理
Transcranial ultrasound therapy uses focused acoustic energy to induce therapeutic bioeffects in the brain. Ultrasound must be transmitted through the skull, which is highly attenuating and heterogeneous, causing beam distortion, reducing…
The coil in transcranial magnetic stimulation (TMS) determines the spatial shape of the electromagnetic field in the head, which structures are concurrently activated, and how focal stimulation is. Most of the readily available coils have…
Background: After its first ex-vivo and in-vivo demonstration, Positronium Lifetime Imaging (PLI) has received considerable interest as a potential new diagnostic biomarker. High sensitivity Positron Emission Tomography (PET) systems are…
Purpose: Annotation of medical breast images is an essential step toward better diagnostic but a time consuming task. This research aims to focus on different selecting sample strategies within deep active learning on Breast Region…
To develop a machine learning-based framework for accurately modeling the anode heel effect in Monte Carlo simulations of X-ray imaging systems, enabling realistic beam intensity profiles with minimal experimental calibration. Multiple…
In this paper, we develop a nonconservative kinetic framework to be applied to the study of immune system dysregulation. From the modeling viewpoint, the model regards a system composed of stochastically interacting agents, under the action…
We propose an ultrasound approach which provides, with one single examination and one single device, access to three bone biomarkers: anatomy, tissue quality and blood flow. It unlocks ultrasound imaging inside bone by accounting for…
In this study, we present a highly sensitive Surface Plasmon Resonance (SPR)-based biosensor integrated with a circular-lattice Photonic Crystal Fiber (PCF) for early-stage cancer detection. The proposed sensor leverages the synergy between…
Purpose: Inhomogeneous magnetization transfer (ihMT) effect reflects dipolar order with a dipolar relaxation time ($T_{1D}$), specific to motion-restricted macromolecules. We aim to quantify $T_{1D}$ using spin-lock MRI technique. Methods:…
Three-dimensional (3D) ultrasound provides enhanced visualization of the carotid artery (CA) anatomy and volumetric flow, offering improved accuracy for cardiovascular diagnosis and monitoring. However, fully populated matrix transducers…
Whole-brain radiotherapy (WBRT) is a common treatment due to its simplicity and effectiveness. While automated Field-in-Field (Auto-FiF) functions assist WBRT planning in modern treatment planning systems, it still requires manual…
Wearable technologies have the potential to transform ambulatory and at-home hemodynamic monitoring by providing continuous assessments of cardiovascular health metrics and guiding clinical management. However, existing cuffless wearable…
Zero-dimensional cardiovascular models provide a computationally efficient framework for studying global hemodynamic behavior, yet the influence of model complexity on parameter sensitivity remains insufficiently understood. This work…
In this work, we proposed virtual imaging simulators as an alternative approach to experimental validation of beam range uncertainty in complex patient geometry using a computational model of a human head and a photon-counting CT scanner.…
Elevated kurtosis values have been observed in subcortical grey matter structures of patients with neurodegenerative diseases. Here we tested whether these elevated values are related to iron content, which generate magnetic fields that add…
Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease that leads to increased pulmonary pressures, vascular remodeling, and eventual right ventricular (RV) failure. Pediatric PAH remains understudied due to limited…
This study presents the design, simulation, and experimental validation of a dual-tuned concentric multimodal surface coil for 7T 1H/31P magnetic resonance spectroscopic imaging (MRSI), developed to significantly enhance 31P B1 efficiency…
Lung cancer remains the leading cause of cancer-related mortality worldwide, with survival strongly dependent on early detection. Standard-dose computed tomography (CT) screening using the Lung Imaging Reporting and Data System (Lung-RADS)…
Fourier ptychographic microscopy (FPM) is a promising quantitative phase imaging technique that enables high-resolution, label-free imaging over a large field-of-view. Here, we present the first application of FPM for the quantitative…
High-resolution voxel-based micro-finite element ($\mu$FE) models derived from $\mu$CT imaging enable detailed investigation of bone mechanics but remain computationally challenging at anatomically relevant scales. This study presents a…