医学物理
In positron emission tomography (PET), a clear theoretical model describing how system sensitivity varies as a source is moved trans-axially within the field of view (FOV) is lacking. The current understanding and practical intuition often…
We present the development and validation of a novel multimodal optical imaging platform that integrates hyperspectral imaging (HSI) and laser speckle contrast imaging (LSCI) to enable real-time, non-invasive mapping of tissue oxygenation,…
This report presents the MOD{\`E}FONE project, whose objective is to develop a simplified experimental model of the cerebrospinal system in order to investigate fluid-structure interactions and physiological adaptations under altered…
Proton minibeam (pMB) radiotherapy, delivers highly heterogeneous dose distributions alternating high-dose peaks and low-dose valleys. This aims to widen the therapeutic window by improving normal tissue sparing while maintaining the same…
LiDRoSIS is an automated MATLAB-Python software suite for the segmentation and quantification of lipid droplets (LDs) and reactive oxygen species (ROS) in fluorescence microscopy images of irradiated A549 and MCF7 cells exposed to…
Ultrasound-based elasticity imaging is a non-invasive technique for estimating tissue stiffness fields from displacement fields obtained by comparing ultrasound signals before and after compression. While recent deep learning approaches…
Intensity-modulated proton therapy (IMPT) employs proton radiation rather than conventional X-rays to treat cancerous tumors. This approach offers significant advantages by minimizing the radiation exposure of surrounding healthy tissue,…
Transcranial ultrasound must overcome the significant challenge of the human skull, limiting both imaging and therapeutic applications. While high-fidelity numerical simulations can compensate for skull-induced distortions, they require…
We present MONAS (MicrOdosimetry-based modelliNg for relative biological effectiveness (RBE) ASsessment) toolkit. MONAS is a TOPAS Monte Carlo extension, that combines simulations of microdosimetric distributions with radiobiological…
Treatment delivery is largely determined by capabilities of the beam delivery system (BDS), where faster delivery can have many potential benefits including improved dosimetric quality, utility, cost effectiveness, patient throughput and…
Active arterial mechanics, governed by vascular smooth muscle contraction, are critical to physiological regulation, cardiovascular disease progression, and clinical diagnosis. Although various in vivo methods have been developed to assess…
Ultrasound vortices have rapidly expanded their applications to areas like particle trapping, contactless manipulation, acoustic communications. In ultrasonic imaging and therapy involving bone tissues, these vortex beams offer intriguing…
Pencil beam scanning (PBS) proton therapy provides highly conformal dose distributions that are increasingly leveraged for postmastectomy radiation therapy (PMRT) to reduce cardiopulmonary exposure. However, implant-based reconstruction in…
Single-channel SQUID system technology, operating at a noise level of 100s of aT/$\sqrt{\textrm{Hz}}$, enables the non-invasive detection of synchronized spiking activity at the single-trial level via magnetoencephalography (MEG). However,…
Head and neck cancer (HNC) patients who undergo radiotherapy (RT) may experience anatomical changes during treatment, compromising the validity of the initial treatment plan, necessitating replanning. However, replanning disrupts clinical…
Digital twins are virtual replicas of physical entities and are poised to transform personalized medicine through the real-time simulation and prediction of human physiology. Translating this paradigm from engineering to biomedicine…
Background: X-ray dark-field radiography uses small-angle scattering to visualize the structural integrity of lung alveoli. To study the influence of dose reduction on clinical dark-field radiographs, one can simulate low-dose images by…
Magnetic resonance imaging (MRI) has revolutionized medical imaging, providing a non-invasive and highly detailed look into the human body. However, the long acquisition times of MRI present challenges, causing patient discomfort, motion…
Personalized computed tomography (CT) dosimetry has great potential in assessing patient-specific radiation exposure, supporting risk assessment, and optimizing clinical protocols. The aim of this study is to evaluate the potential of…
Geometric uncertainty can degrade treatment quality in radiation therapy. While margins and robust optimization mitigate these effects, they provide only implicit control over clinical goal fulfillment probability. We therefore develop a…