医学物理
Cryopreservation via vitrification requires loading cryoprotective cocktails. Insufficient loading may lead to freezing, precluding successful recovery; overloading is toxic. Yet, existing in situ measurements of cryoprotectant permeation…
The regeneration of oral and craniofacial bone defects ranging from minor periodontal and peri-implant defects to large and critical lesions imposes a substantial global health burden. Conventional therapies are associated with several…
Background: Palpation is the most widely used approach to empirically assess the mechanical properties of superficial tissues. While elastography is used for volume measurements, it remains difficult to assess skin properties with…
Measuring the dynamics and mechanical properties of muscles and joints is important to understand the (patho)physiology of muscles. However, acquiring dynamic time-resolved MRI data is challenging. We have previously developed…
Hearts subjected to volume overload (VO) are prone to detrimental anatomical and functional changes in response to elevated mechanical loading, ultimately leading to heart failure. Experimental findings now emphasize that organ-scale…
Positron range (PR) limits spatial resolution and quantitative accuracy in PET imaging, particularly for high-energy positron-emitting radionuclides like 68Ga. We propose a deep learning method using 3D residual encoder-decoder…
Purpose: While spiral sampling offers SNR advantages for diffusion MRI, its acceleration with simultaneous multislice remains relatively unexplored. This study introduces Laterally Oscillating Trajectory for Undersampling Slices (LOTUS),…
This is the second article in a series of three dealing with the exploitation of speckle for aberration correction and reverberation compensation in reflection imaging. When probing heterogeneous media with waves, we have to cope with…
A wide range of diagnostic information in medicine is currently obtained using radioactive tracers. While central to nuclear medicine, these methods are inherently constrained: radiation dose limits repeat examinations, short tracer…
Spectro-microscopy is an experimental technique which can be used to observe spatial variations in chemical state and changes in chemical state over time or under experimental conditions. As a result it has broad applications across areas…
Scattered coincidences introduce quantitative bias in positron emission tomography (PET) and must be compensated during reconstruction. Conventional scatter estimates typically rely on simplified cylindrical scanner models that omit…
Implementing electrophysiological recordings within an MRI environment is challenging due to complex interactions between recording probes and MRI-generated fields, which can affect both safety and data quality. This study aims to develop…
Background: Perfusion computed tomography (CT) images the dynamics of a contrast agent through the body over time, and is one of the highest X-ray dose scans in medical imaging. Recently, a theoretically justified reconstruction algorithm…
We proposed a new approach, which is inspired by the method of super-resolution (SR) structured illumination microscopy (SIM) for overcoming the resolution limit in microscopy due to diffraction of light, for increasing the resolution of…
Many modern ultrasound beamformers report improved image quality when evaluated using classical criteria like the contrast ratio and contrast-to-noise ratio, which are based on summary statistics of regions of interest (ROIs). However,…
This study introduces a novel integration of the Brainstorm (BST) software and the Zeffiro Interface (ZI) to enable whole-head, multi-compartment volume conductor modeling for electroencephalography (EEG) source imaging, with a particular…
The POSiCS camera is a handheld, small field-of-view gamma camera developed for multipurpose use in radio-guided surgery (RGS), with sentinel lymph node biopsy (SLNB) as its benchmark application. This compact and lightweight detector…
Background: Material structures at the micrometer scale cause ultra-small-angle X-ray scattering, e.g., seen in lung tissue or plastic foams. In grating-based X-ray imaging, this causes a reduction of the fringe visibility, forming a…
Prostate cancer is one of the most prevalent and deadly cancers among men, motivating the development of accurate and accessible imaging technologies for early detection. Ultrasound computed tomography (USCT) reconstructs quantitative…
Water diffusion gives rise to micron-scale sensitivity of diffusion MRI (dMRI) to cellular-level tissue structure. Precision medicine and quantitative imaging depend on uncovering the information content of dMRI and establishing its…