医学物理
Quantification of protoporphyrin IX (PpIX) fluorescence in human brain tumours has the potential to significantly improve patient outcomes in neuro-oncology, but represents a formidable imaging challenge. Protoporphyrin is a biological…
Infrared thermography has gained interest as a tool for non-contact measurement of blood circulation and skin blood flow due to cardiac activity. Partiularly, blood vessels on the surface, such as on the back of the hand, are suited for…
Purpose: Interpretability is essential for the clinical adoption of state-of-the-art machine learning (ML) methods in magnetic resonance imaging (MRI). Conventional evaluation of ML reconstructions relies heavily on aggregate image metrics…
Purpose: Spinal instability is a widespread condition that causes pain, fatigue, and restricted mobility, profoundly affecting patients' quality of life. In clinical practice, the gold standard for diagnosis is dynamic X-ray imaging.…
This study demonstrates the feasibility of a novel fabrication technique for high spatial resolution CsI: Tl scintillation detectors tailored for single photon emission computed tomography (SPECT) systems. Building upon our previously…
Radiopharmaceutical therapies are expanding rapidly, but clinical evidence generation is limited by operational constraints and biological heterogeneity in radiopharmaceutical delivery and radiation risk. Virtual theranostic trials can run…
Purpose: We developed a dynamic B0 shimming approach using a 46-channel AC/DC shim array to correct phase errors caused by eddy currents from diffusion-encoding gradients in diffusion-prepared MRI, enabling high b-value imaging without the…
Vascular remodelling is inherent to the pathogenesis of many diseases including cancer, neurodegeneration, fibrosis, hypertension, and diabetes. In this paper, a new susceptibility-contrast based MRI approach is established to analyse…
This study aims to model the evaporation residues produced by the interaction of 108-170 MeV of 20Ne with the 181Ta target using Monte-Carlo PACE4 simulation code. Reaction mechanisms taking place in these interactions along with production…
Purpose: Accurate prediction of beam delivery time (BDT) is essential for operational efficiency, 4D dose calculations, and advanced proton therapy techniques. Despite its importance, no machine-specific BDT model exists for Mevion systems.…
Blood pressure regulation is commonly addressed in terms of local mechanisms such as vascular resistance, compliance and neurohumoral control. However, the human vasculature encompasses multiple quasi-closed flow loops under both…
Significance: Cervical cancer progresses through cervical intraepithelial neoplasia (CIN), which are precursor lesions of cervical cancer. In low-grade CIN, atypical cells generate inside the squamous epithelium, which causes the accuracy…
In this work, we propose a free-breathing magnetic resonance fingerprinting method that can be used to obtain $B_1^+$-robust quantitative maps of the abdomen in a clinically acceptable time. A three-dimensional MR fingerprinting sequence…
Dynamic volumetric MRI provides valuable information on in vivo motion and biomechanics, with applications spanning cardiac, musculoskeletal, or pulmonary imaging, amongst others. Developing reconstruction methods for time-resolved…
Structured light (SL)-induced polarization perception presents a promising method for the early detection of macular diseases such as age-related macular degeneration. We investigated the test-retest reliability of a psychophysical task…
Objectives. This study develops and validates a vacuum-based alpha irradiation platform to support preclinical radiobiology. We aim to demonstrate precise, independent control over incident energy, fluence rate, and spatiotemporal patterns,…
This study presents the first ex-vivo positronium imaging of human tissues using the modular J-PET scanner with the $^{44}$Sc radionuclide. The $^{44}$Sc isotope was produced via the $^{44}$Ca(p, n)$^{44}$Sc nuclear reaction and used to…
Three-dimensional (3D) multi-slab imaging is a promising approach for high-resolution in vivo diffusion MRI (dMRI) due to its compatibility with short TR (1-2 s), providing optimal signal-to-noise ratio (SNR) efficiency. A major challenge,…
Cryopreservation via vitrification requires loading cryoprotective cocktails. Insufficient loading may lead to freezing, precluding successful recovery; overloading is toxic. Yet, existing in situ measurements of cryoprotectant permeation…
The regeneration of oral and craniofacial bone defects ranging from minor periodontal and peri-implant defects to large and critical lesions imposes a substantial global health burden. Conventional therapies are associated with several…