医学物理
MR experiments are essential for studying brain metabolism, yet preclinical 1H-MRSI remains underdeveloped, with significant limitations in SNR, acquisition speed, and automated data processing. Although recent advances-such as accelerated…
Purpose: Magnetization transfer (MT) has been identified as the principal source of $T_1$ variability in the MRI literature. This study assesses the sensitivity of established $T_1$ mapping techniques to variations in the underlying MT…
This work introduces CTorch, a PyTorch-compatible, GPU-accelerated, and auto-differentiable projector toolbox designed to handle various CT geometries with configurable projector algorithms. CTorch provides flexible scanner geometry…
Continuous monitoring of blood pressure (BP) and hemodynamic parameters such as peripheral resistance (R) and arterial compliance (C) are critical for early vascular dysfunction detection. While photoplethysmography (PPG) wearables has…
We introduce a denoising method for four-dimensional scanning transmission electron microscopy (4D-STEM) that relies on processing local, scan position-independent electron event-sparse data stacks, called event-sparse stack denoising. This…
Simulation-guided transcranial focused ultrasound therapies rely on estimating skull acoustic properties from pretreatment imaging. Typical clinical resolution (0.5 mm isotropic) cannot resolve bone microstructure, making the acoustic…
Transcranial focused ultrasound applications often use simulations that require accurate acoustic properties, which can be related to computed tomography (CT) Hounsfield Units (HU). However, clinical CT is insensitive to microstructure.…
Purpose: HDR brachytherapy is a widely adopted modality for cancer treatment. However, it is not free from error and uncertainty. In-vivo dosimetry (IVD) is the only technique that can confirm correct dose delivery. This study details and…
Background: Accurate proton resonance frequency (PRF) MR thermometry is essential for monitoring temperature rise during thermal ablation with high intensity focused ultrasound (FUS). Conventional referenceless methods such as complex field…
We studied the structural alterations between healthy and diseased brain tissues using a multiparametric framework combining fractal analysis, fractal functional transformation, multifractal analysis, and the Inverse Participation Ratio…
Alzheimer's disease (AD) is characterized by progressive microstructural deterioration in brain tissue, yet conventional imaging and histopathology often lack the sensitivity needed to detect subtle early-stage changes. Here, we present a…
Subject-specific cardiovascular models rely on parameter estimation using measurements such as 4D Flow MRI data. However, acquiring high-resolution, high-fidelity functional flow data is costly and taxing for the patient. As a result, there…
Parkinson disease (PD) is marked by progressive neurodegeneration, yet early and subtle structural alterations in brain tissue remain difficult to detect with conventional imaging and analytical methods. Fractal and multifractal frameworks…
Superparamagnetic iron oxide nanoparticles (SPIONs) such as ferumoxytol are promising theranostic agents detectable with MRI. Relaxation time mapping offers reproducible, quantitative biomarkers of SPION distribution, but conventional…
Transient brain-wide neuroimaging on a microscopic scale is pivotal for brain research, yet current modalities face challenges in meeting such spatiotemporal requirements. Functional ultrasound (fUS) enables transient neurovascular imaging…
Accurate prediction of aortic expansion in uncomplicated type B aortic dissection (TBAD) can help identify patients who may benefit from timely thoracic endovascular aortic repair. This study investigates associations between biomechanical…
The electrocardiogram (ECG) is used for diagnosis and risk stratification in myocardial infarction (MI). Women have a higher incidence of missed MI diagnosis and complications following infarction, and to address this we aim to provide…
Mounting evidence for markedly increased cerebellar Gd retention under neuroinflammatory conditions after repeated linear gadolinium-based contrast agents (GBCA) administration in vivo, makes necessary a discrimination between Gd retained…
Spatially Fractionated Radiation Therapy (SFRT) produces highly heterogeneous dose distributions, for which conventional metrics such as peak, valley, or average dose can yield ambiguous or inconsistent estimates of therapeutic window…
Biophysical models in diffusion MRI (dMRI) hold promise for characterizing gray matter tissue microstructure. Yet, the reliability of their parameter estimates remains largely under-studied, especially in models that incorporate water…