医学物理
Conventional near-infrared spectroscopy (NIRS) instruments typically employ 2-3 wavelengths for monitoring tissue haemodynamics. However, the use of broadband illumination (hundreds of wavelengths) unlocks also the targeting of tissue…
This work introduces a quantitative method for assessing calcification in fibrocartilage using spectral micro-computed tomography ($\mu$CT). Tissue samples of hip acetabular labrum from patients with osteoarthritis and femoroacetabular…
Cone-beam computed tomography (CBCT) is an imaging modality widely used in head and neck diagnostics due to its accessibility and lower radiation dose. However, its relatively long acquisition times make it susceptible to patient motion,…
Histopathological examination of surgical biopsies, such as in glioma and glioblastoma resection, is hindered in current clinical practice by the long times required for the laboratory analysis and pathological screening, typically taking…
Excitable tissue is fundamental to brain function, yet its study is complicated by extreme morphological complexity and the physiological processes governing its dynamics. Consequently, detailed computational modeling of this tissue…
When irradiation is performed with gold nanoparticles (AuNPs), a different shape of cells in suspension or adherent to walls may result in different probability of cell survival. In a recent study, differences of up to a factor of 2 were…
In radiobiological experiments, the cells can either float in suspension or adhere to the walls of the sample holder. When irradiation is performed in the presence of dose modifying agents such as gold nanoparticles (AuNPs), the different…
Magnetic Resonance Imaging (MRI) is the gold standard in countless diagnostic procedures, yet hardware complexity, long scans, and cost preclude rapid screening and point-of-care use. We introduce Imageless Magnetic Resonance Diagnosis…
Nuclear magnetic resonance instruments are becoming available to the do-it-yourself community. The challenges encountered in the endeavor to build a magnetic resonance imaging instrument from scratch were confronted in a four-day hackathon…
This paper presents a practical guide to prepare inorganic solutions that mimic the photoacoustic properties of whole blood at specific levels of oxygenation in the range of 700 nm to 850 nm, both in terms of optical absorption properties…
The Standardized Uptake Value (SUV) is a critical metric in positron emission tomography (PET) imaging, used to assess metabolic activity. However, calculating SUV from DICOM files presents challenges due to vendor-specific DICOM attributes…
Proton magnetic resonance spectroscopic imaging (1H-MRSI) at ultra-high field has seen an increase in usage in the preclinical field. Challenges related to long acquisition time and low concentration of brain metabolites in the rodent brain…
Magnetic resonance imaging-guided linear accelerators (MRI-Linacs) are an emerging treatment technology that enable online soft-tissue visualisation and adaptive radiotherapy. The Australian 1.0 T MRI-Linac employs a fixed, inline beamline,…
Objective: Hyper-clutter artifacts (HCA), arising from strong tissue reflections or physiological motion, present persistent challenges in ultrafast ultrasound Doppler imaging, often obscuring surrounding small vessel flow signals,…
Radiomics enables the extraction of quantitative biomarkers from medical images for precision modeling, but reproducibility and scalability remain limited due to heterogeneous software implementations and incomplete adherence to standards.…
Introduction: The rise in public medical imaging datasets has raised concerns about patient reidentification from head CT scans. However, existing defacing algorithms often remove or distort Organs at Risk (OARs) and Planning Target Volumes…
This study presents a frequency-domain, Hessian-free ray-Born inversion method for quantitative ultrasound tomography, extending the author's previous Hessian-based approach. Both approaches model acoustic wave propagation using a ray-based…
Three-dimensional ultrasound localization microscopy (ULM) enables comprehensive visualization of the vasculature, thereby improving diagnostic reliability. Nevertheless, its clinical translation remains challenging, as the exponential…
The equinus foot is a neuromuscular condition that affects ankle dorsiflexion, impairing gait and reducing quality of life. This study presents EquiSay, a dynamic anti-equinus orthosis equipped with an anterior elastic tension system and an…
Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…