医学物理
A multi-objective framework for hydrogen supply chain (HSC) planning is developed for island contexts, incorporating Mixed-Integer Linear Programming (MILP) over multiple time periods. The model minimizes total system cost, greenhouse gas…
Background: In vivo dosimetry is essential for treatment verification in modern radiotherapy, but existing techniques are limited by spatiotemporal resolution and performance on non-uniform anatomy. Scintillation imaging dosimetry shows…
Objectives: Mn-based MRI contrast agents (MBCAs) have recently been proposed as alternatives to the currently used class of Gd-chelates. Unlike Gd, Mn is an endogenous paramagnetic metal with known biochemical pathways in the human body for…
The transformative potential of artificial intelligence (AI) in medical Imaging (MI) is well recognized. Yet despite promising reports in research settings, many AI tools fail to achieve clinical adoption in practice. In fact, more…
Purpose: To demonstrate in-vivo imaging with a low-cost, low-field MRI scanner built and operated in Africa, and to show how systematic hardware and software improvements can mitigate the main operational limitations encountered in…
Estimation of thermal contact resistances between cylinders can be achieved using heating on the cross sections by a laser spot and measurement of the temperature response by IR thermography. This type of measurement makes it possible to…
Abdominal aortic aneurysm (AAA) wall stress is a candidate rupture risk marker but is typically computed from single-phase images without known cardiac phase. Linear stress recovery methods, which solve a single geometrically linear…
The field of Clinical-Computational Nuclear Medicine is rapidly advancing, fueled by AI, tracer kinetic modeling, radiomics, and integrated informatics. These technologies improve imaging quality, automate lesion detection, and enable…
Alzheimer disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable…
Dissolution Dynamic Nuclear Polarisation (dDNP) increases the sensitivity of magnetic resonance experiments by $>10^4$-fold, permitting isotopically-labelled molecules to be transiently visible in MRI scans. dDNP requires a source of…
This study introduces a novel metric, Plan Aperture Modulation (PAM), developed to quantify the modulation of radiotherapy treatment plans. PAM aims to provide a clear geometric interpretation, addressing the limitations of previous…
Objectives: To evaluate the association between pretreatment MRI descriptors and breast cancer (BC) pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). Materials \& Methods: Patients with BC treated by NAC with a breast…
Current acoustic radiation force (ARF) based methods for quantifying tissue elasticity primarily rely on shear wave propagation. However, their spatial resolution is limited by the need for spatial averaging, and their accuracy is affected…
Stereotactic Arrhythmia Radiotherapy (STAR) treats ventricular tachycardia (VT) but requires internal target volume (ITV) expansions to compensate for cardiorespiratory motion. Current clinical r4DCT imaging methods are limited, and the…
This study presents the first experimental validation of a Hessian-free ray-Born inversion technique for quantitative reconstruction of sound speed from transmission ultrasound data. The method combines single-scattering theory with…
Purpose: To develop the first 3D optic nerve head (ONH) atlas using AI-based registration and evaluate its use in: (1) atlas-adjusted retinal nerve fiber layer (RNFL) analysis for glaucoma diagnosis, and (2) strain-based assessment of…
Long-axial field-of-view (LAFOV) PET/CT has the potential to redefine the role of molecular imaging in theranostics by making multiparametric whole-body (MPWB) imaging and predictive dosimetry more clinically feasible. Compared to…
Photoacoustic (PA) imaging of deep tissue tends to employ Q-switched lasers with high pulse energy to generate high optical fluence and therefore high PA signal. Compared to Q-switched lasers, pulsed laser diodes (PLDs) typically generate…
In this study, we present the Physical-Bio Translator, an agent-based simulation model designed to simulate cellular responses following irradiation. This simulation framework is based on a novel cell-state transition model that accurately…
Purpose: To demonstrate the feasibility of performing in vivo imaging and quantitative relaxation mapping of soft and hard tissues using a low-cost, portable MRI scanner, and to establish the methodological foundations for zero echo time…