The automorphism group of an affine quadric

We determine the automorphism group for a large class of affine quadric hypersurfaces over a field, viewed as affine algebraic varieties. In particular, we find that the group of real polynomial automorphisms of the n-sphere is just the orthogonal group O(n+1) whenever n is a power of 2. It is not known whether the same is true for arbitrary n. The proof uses Karpenko's theorem that certain projective quadrics over a field are not ruled. That is, they are not birational over the given field to the product of any variety with the projective line. We also formulate a general result on automorphisms of affine varieties. We conclude by conjecturing a converse to Karpenko's theorem, predicting exactly which projective quadrics are ruled.