动物发育与生命阶段本体的构建与统一
定量方法
2022-06-27 v1
摘要
随着基因组学的新时代到来，越来越多动物物种可进行大规模数据生成。这促使了新的多物种本体涌现，以注释和组织这些数据。尽管这些工作已较好覆盖了解剖学与细胞类型，但发育与生命阶段信息对于动物数据的注释同样关键。其缺失会妨碍我们回答比较生物学问题并解释功能结果。我们在此呈现了面向 21 个动物物种的发育与生命阶段本体集合，并将它们合并为一个通用的多物种本体。该工作使得 52 个动物物种的转录组学数据得以整合与比较。
引用
@article{arxiv.2206.12231,
title = {Creation and unification of development and life stage ontologies for animals},
author = {Anne Niknejad and Christopher J. Mungall and David Osumi-Sutherland and Marc Robinson-Rechavi and Frederic B. Bastian},
journal= {arXiv preprint arXiv:2206.12231},
year = {2022}
}
备注
2 pages, 1 table, accepted at Bio-Ontologies COSI ISMB 2022 conference. AN developed species-specific ontologies, links to Uberon. CJM and DOS developed Uberon life-stage ontology, ontology design principles. DOS developed fly ontology. MRR contributed work supervision. FBB supervised the work, built the integration to Uberon, and wrote the paper. CJM, DOS and FBB maintain the repository