相关论文: Does Recycling in Germinal Centers Exist?
In this note, we focus on a selection model problem: a mono-exponential model versus a bi-exponential one. This is done in the biological context of living cells, where small data are available. Classical statistics are revisited to improve…
This question is raised by Cason, Friedman and Hopkins (CFH, 2012) after they firstly found and indexed quantitatively the cycles in a continuous time experiment. To answer this question, we use the data from standard RPS experiment. Our…
A univariate clustering criterion for stationary processes satisfying a $\beta$-mixing condition is proposed extending the work of \cite{KB2} to the dependent setup. The approach is characterized by an alternative sample criterion function…
A novel theory for cell differentiation is proposed, based on simulations with interacting artificial cells which have metabolic networks within, and divide into two when the final product is accumulated. Results of simulations with coupled…
It is now commonly accepted that globular clusters (GCs) have undergone a complex formation and that they host at least two stellar generations. This is a recent paradigm and is founded on both photometric and spectroscopic evidence. We…
A new criterion is developed which provides a check as to whether a chosen set of polarization observables is complete with respect to the determination of all independent $T$-matrix elements of a reaction of the type $a+b\to c+d+...$. As…
The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate…
Conceptualizing planetary habitability depends on understanding how living organisms originated and what features of environments are essential to foster abiogenesis. Estimates of the abundance of life's building blocks are confounded by…
We propose an alternative to the prevailing two origin of life narratives, one based on a replicator first hypothesis, and one based on a metabolism first hypothesis. Both hypotheses have known difficulties: All known evolvable molecular…
Cell formation problem is among the first obstacles the designer of cellular production systems must overcome. This paper presents a critical analysis of the various criteria and constraints considered in the literature. The objective is to…
In this research, we consider a mixture of genome fragments of a certain bacteria set. The problem of mixture separation is studied under the assumption that all the genomes present in the mixture are completely sequenced or are close to…
We first discuss recent progress in using the Milky Way globular cluster (GC) system as a `test-bed' for properties derived from integrated spectra and stellar population models. Standard techniques may give rise to spuriously high…
During germinal center reactions the appearance of two specific zones is observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model…
Temporal evolution of a clonal bacterial population is modelled taking into account reversible mutation and selection mechanisms. For the mutation model, an efficient algorithm is proposed to verify whether experimental data can be…
We propose that structural, kinematical, and chemical properties of the Galactic globular clusters (GCs) can contain fossil information of the cosmic reionization history. We first summarize possible observational evidences for the…
We consider a reaction-diffusion system which may serve as a model for a ferment catalytic reaction in chemistry. The model consists of a system of reaction diffusion equations with unbounded time dependent coefficients and different…
The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called "rearrangement" forming progenitor B cells, then a Darwinian…
Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in…
Let $G$ be a group. We say that an element $f\in G$ is {\em reversible in} $G$ if it is conjugate to its inverse, i.e. there exists $g\in G$ such that $g^{-1}fg=f^{-1}$. We denote the set of reversible elements by $R(G)$. For $f\in G$, we…
A dynamic model for cell differentiation is studied, where cells with internal chemical reaction dynamics interact with each other and replicate. It leads to spontaneous differentiation of cells and determination, as is discussed in the…