Cell cycle heritability and localization phase transition in growing populations
Populations and Evolution
2021-01-04 v1 Statistical Mechanics
Biological Physics
Abstract
The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate existence of a phase transition, which can be continuous or first-order, by which a non-zero fraction of the population becomes localized at a minimal division time. Just below the transition, we demonstrate coexistence of localized and delocalized age-structure phases, and power law decay of correlation functions. Above it, we observe self-synchronization of cell cycles, collective divisions, and slow 'aging' of population growth rates.
Cite
@article{arxiv.2003.05350,
title = {Cell cycle heritability and localization phase transition in growing populations},
author = {Takashi Nozoe and Edo Kussell},
journal= {arXiv preprint arXiv:2003.05350},
year = {2021}
}