相关论文: Does Recycling in Germinal Centers Exist?

The process of genetic recombination can be seen as a chemical reaction network with mass-action kinetics. We review the known results on existence, uniqueness, and global stability of an equilibrium in every compatibility class and for all…

In the paper we propose certain conditions, relatively easy to verify, which ensure the central limit theorem for some general class of Markov chains. To justify the usefulness of our criterion, we further verify it for a particular…

Reproducibility is central to the credibility of scientific findings, yet complete replication studies are costly and infrequent. However, many biological experiments contain internal replication, which is defined as repetition across…

We present a detailed dynamical model of the behavior of transcription-translation circuits in vitro that makes explicit the roles played by essential molecular resources. A set of simple two-gene test circuits operating in a cell-free…

It is shown that the traditional approach for consideration of recombination under condition of steady-state current in the absence of external carrier generation is internally contradictory. Sometimes the approach leads to obviously…

In the paper we obtain the existence criterion of a Carter subgroup in a finite group in terms of its normal series. An example showing that the criterion cannot be reformulated in terms of composition factors is given.

The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through…

We study properties of !-limit sets of multivalued semiflows like chain recurrence or the existence of cyclic chains. First, we prove that under certain conditions the omega-limit set of a trajectory is chain recurrent, applying this result…

In rule-based systems, goal-oriented computations correspond naturally to the possible ways that an observation may be explained. In some applications, we need to compute explanations for a series of observations with the same domain. The…

Globular Clusters (GCs) exhibit star-to-star variations in specific elements (e.g., He, C, N, O, Na, Al) that bare the hallmark of high temperature H burning. These abundance variations can be observed spectroscopically and also…

Clustering of molecules on biological membranes is a widely observed phenomenon. In some cases, such as the clustering of Ras proteins on the membranes of mammalian cells, proper cell signaling is critically dependent on the maintenance of…

Motility is characteristic of life, but a common basis for movement has remained to be identified. Diverse systems in motion shift between two states depending on interactions that turnover at the rate of an applied cycle of force. Although…

Based on our studies done on two-dimensional autonomous systems, forced non-autonomous systems and time-delayed systems, we propose a unified methodology - that uses renormalization group theory - for finding out existence of periodic…

Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of…

Cells coexist together in colonies or as tissues. Their behaviour is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network…

Some of the centrality experiments indicate regime change and saturation in the behavior of characteristics of the secondary particles. It is observed as a critical phenomenon for hadron-nuclear, nuclear-nuclear interactions and…

Using an averaged generating function for coloured hard-dimers, some random variables of interest are studied. The main result lies in the fact that all their probability distributions obey a central limit theorem.

We analyze a reaction-diffusion system describing the growth of microbial species in a model of flocculation type that arises in biology. Existence of global classical positive solutions is proved under general growth assumptions, with…

There is compelling observational evidence that globular clusters (GCs) are quite complex objects. A growing body of photometric results indicate that the evolutionary sequences are not simply isochrones in the observational plane -as…

It is well known that the classical recombination equation for two parent individuals is equivalent to the law of mass action of a strongly reversible chemical reaction network, and can thus be reformulated as a generalised gradient system.…