Mutation and selection in bacteria: modelling and calibration
Populations and Evolution
2019-04-03 v2 Probability
Quantitative Methods
Abstract
Temporal evolution of a clonal bacterial population is modelled taking into account reversible mutation and selection mechanisms. For the mutation model, an efficient algorithm is proposed to verify whether experimental data can be explained by this model. The selection-mutation model has unobservable fitness parameters and, to estimate them, we use an Approximate Bayesian Computation (ABC) algorithm. The algorithms are illustrated using in vitro data for phase variable genes of Campylobacter jejuni.
Cite
@article{arxiv.1803.01767,
title = {Mutation and selection in bacteria: modelling and calibration},
author = {C. D. Bayliss and C. Fallaize and R. Howitt and M. V. Tretyakov},
journal= {arXiv preprint arXiv:1803.01767},
year = {2019}
}
Comments
35 pages. The accepted version by The Bulletin of Mathematical Biology