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The computational study of conformational transitions in RNA and proteins with atomistic molecular dynamics often requires suitable enhanced sampling techniques. We here introduce a novel method where concurrent metadynamics are integrated…

计算物理 · 物理学 2015-09-01 Alejandro Gil-Ley , Giovanni Bussi

The stochastic matching problem deals with finding a maximum matching in a graph whose edges are unknown but can be accessed via queries. This is a special case of stochastic $k$-set packing, where the problem is to find a maximum packing…

数据结构与算法 · 计算机科学 2015-04-30 Avrim Blum , John P. Dickerson , Nika Haghtalab , Ariel D. Procaccia , Tuomas Sandholm , Ankit Sharma

This paper addresses patient heterogeneity associated with prediction problems in biomedical applications. We propose a systematic hypothesis testing approach to determine the existence of patient subgroup structure and the number of…

统计方法学 · 统计学 2021-01-08 Xu Gao , Weining Shen , Jing Ning , Ziding Feng , Jianhua Hu

State-of-the-art entity matching (EM) methods are hard to interpret, and there is significant value in bringing explainable AI to EM. Unfortunately, most popular explainability methods do not work well out of the box for EM and need…

数据库 · 计算机科学 2022-08-17 Nils Barlaug

In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs…

组织与器官 · 定量生物学 2025-02-20 Charlotte A Veser , Aurélie MF Carlier , Silvia M Mihăilă , Sangita Swapnasrita

Efficient implementations of parallel applications on heterogeneous hybrid architectures require a careful balance between computations and communications with accelerator devices. Even if most of the communication time can be overlapped by…

分布式、并行与集群计算 · 计算机科学 2014-09-22 Raphaël Bleuse , Thierry Gautier , João V. F. Lima , Grégory Mounié , Denis Trystram

We study the fair allocation problem of indivisible items with subsidy. In this paper, we focus on the notion of fairness - equitability (EQ), which requires that items be allocated such that all agents value the bundle they receive…

计算机科学与博弈论 · 计算机科学 2025-09-10 Yuanyuan Wang , Tianze Wei

In this paper, a multiple-relay network in considered, in which $K$ single-antenna relays assist a single-antenna transmitter to communicate with a single-antenna receiver in a half-duplex mode. A new Amplify and Forward (AF) scheme is…

信息论 · 计算机科学 2007-10-01 Shahab Oveis Gharan , Alireza Bayesteh , Amir K. khandani

In this paper, we study the problem of fair classification in the presence of prior probability shifts, where the training set distribution differs from the test set. This phenomenon can be observed in the yearly records of several…

机器学习 · 计算机科学 2020-05-08 Arpita Biswas , Suvam Mukherjee

We study an elementary path problem which appears in the pricing step of a column generation scheme solving the kidney exchange problem. The latter aims at finding exchanges of donations in a pool of patients and donors of kidney…

数据结构与算法 · 计算机科学 2022-01-24 Lucie Pansart , Hadrien Cambazard , Nicolas Catusse

Covariate shift in the test data is a common practical phenomena that can significantly downgrade both the accuracy and the fairness performance of the model. Ensuring fairness across different sensitive groups under covariate shift is of…

机器学习 · 计算机科学 2024-01-09 Shreyas Havaldar , Jatin Chauhan , Karthikeyan Shanmugam , Jay Nandy , Aravindan Raghuveer

In this paper, we present a novel modelling perspective to the food-bank donation allocation problem under equity and efficiency performance measures. Using a penalty factor in the objective function, our model explicitly accounts for both…

最优化与控制 · 数学 2021-11-11 Mohammad Firouz , Linda Li , Daizy Ahmed , Barry Cobb , Feibo Shao

This work deals with a mathematical analysis of sodium's transport in a tubular architecture of a kidney nephron. The nephron is modelled by two counter-current tubules. Ionic exchange occurs at the interface between the tubules and the…

偏微分方程分析 · 数学 2020-05-18 Marta Marulli , Vuk Milisic , Nicolas Vauchelet

We present the first application of MAP-Elites, a quality-diversity algorithm, to trade execution. Rather than searching for a single optimal policy, MAP-Elites generates a diverse portfolio of regime-specialist strategies indexed by…

交易与市场微观结构 · 定量金融 2026-02-02 Robert de Witt , Mikko S. Pakkanen

The global rise in homelessness calls for urgent and alternative policy solutions. Non-profits and governmental organizations alert about the many challenges faced by people experiencing homelessness (PEH), which include not only the lack…

多智能体系统 · 计算机科学 2026-01-29 Alba Aguilera , Nardine Osman , Georgina Curto

Background: Acute kidney injury (AKI) is a common complication in hospitalized patients and a common cause for chronic kidney disease (CKD) and increased hospital cost and mortality. By timely detection of AKI and AKI progression, effective…

We study allocation problems without monetary transfers where agents have correlated types, i.e., hold private information about one another. Such peer information is relevant in various settings, including science funding, allocation of…

理论经济学 · 经济学 2025-03-21 Axel Niemeyer , Justus Preusser

Covariate balance is a conventional key diagnostic for methods used estimating causal effects from observational studies. Recently, there is an emerging interest in directly incorporating covariate balance in the estimation. We study a…

统计方法学 · 统计学 2017-02-14 Qingyuan Zhao , Daniel Percival

In this paper we consider the pairwise kidney exchange game. This game naturally appears in situations that some service providers benefit from pairwise allocations on a network, such as the kidney exchanges between hospitals. Ashlagi et…

计算机科学与博弈论 · 计算机科学 2015-07-21 Hossein Esfandiari , Guy Kortsarz

Win statistics based methods have gained traction as a method for analyzing Hierarchical Composite Endpoints (HCEs) in randomized clinical trials, particularly in cardiovascular and kidney disease research. HCEs offer several key…