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We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use…

细胞行为 · 定量生物学 2023-03-16 Katiana Kontolati , Constantinos Siettos

In many stochastic service systems, decision-makers find themselves making a sequence of decisions, with the number of decisions being unpredictable. To enhance these decisions, it is crucial to uncover the causal impact these decisions…

统计方法学 · 统计学 2023-07-18 Juan C. David Gomez , Amy L. Cochran , Gabriel Zayas-Caban

This paper is concerned with the analysis of a class of impacting systems of relevance in applications: cam-follower systems. We show that these systems, which can be modelled as discontinuously forced impact oscillators, can exhibit…

数学物理 · 物理学 2007-11-08 Gustavo Osorio , Mario di Bernardo , Stefania Santini

We study the versatile performance of networks of coupled circuits. Each of these circuits is composed of a positive and a negative feedback loop in a motif that is frequently found in genetic and neural networks. When two of these circuits…

适应与自组织系统 · 物理学 2015-06-22 Darka Labavić , Hildegard Meyer-Ortmanns

We study homoclinic bifurcations in an interval map associated with a saddle-focus of (2, 1)-type in $\mathbb{Z}_2$-symmetric systems. Our study of this map reveals the homoclinic structure of the saddle-focus, with a bifurcation unfolding…

动力系统 · 数学 2023-07-28 Carter Hinsley , James Scully , Andrey L. Shilnikov

Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…

偏微分方程分析 · 数学 2014-04-03 Mark Chaplain , Mariya Ptashnyk , Marc Sturrock

This work concerns a many-body deterministic model that displays life-like properties as emergence, complexity, self-organization, spontaneous compartmentalization, and self-regulation. The model portraits the dynamics of an ensemble of…

适应与自组织系统 · 物理学 2023-07-11 Alessandro Scirè , Valerio Annovazzi-Lodi

We numerically study the dynamics of run-and-tumble particles confined in two chambers connected by thin channels. Two dominant dynamical behaviors emerge: (i) an oscillatory pumping state, in which particles periodically fill the two…

软凝聚态物质 · 物理学 2015-11-04 M. Paoluzzi , R. Di Leonardo , L. Angelani

We have applied the Melnikov criterion to examine a global homoclinic bifurcation and transition to chaos in a case of the Duffing system with nonlinear fractional damping and external excitation. Using perturbation methods we have found a…

混沌动力学 · 物理学 2016-09-08 Marek Borowiec , Grzegorz Litak , Arkadiusz Syta

Microbes are everywhere, including in and on our bodies, and have been shown to play key roles in a variety of prevalent human diseases. Consequently, there has been intense interest in the design of bacteriotherapies or "bugs as drugs,"…

机器学习 · 统计学 2020-04-13 Travis E. Gibson , Georg K. Gerber

Complex dynamical systems may exhibit multiple steady states, including time-periodic limit cycles, where the final trajectory depends on initial conditions. With tuning of parameters, limit cycles can proliferate or merge at an exceptional…

统计力学 · 物理学 2024-12-03 Sergei Shmakov , Peter B. Littlewood

The attractors of a dynamical system govern its typical long-term behaviour. The presence of many attractors is significant as it means the behaviour is heavily dependent on the initial conditions. To understand how large numbers of…

动力系统 · 数学 2022-06-20 Sishu Shankar Muni

Antibiotic-resistant bacteria has posed a grave threat to public health by causing a number of nosocomial infections in hospitals. Mathematical models have been used to study the transmission of antibiotic-resistant bacteria within a…

种群与进化 · 定量生物学 2016-10-06 Xiuli Cen , Zhilan Feng , Yiqiang Zheng , Yulin Zhao

We propose a system of differential equations modeling the competition between two obligate mutualistic species for a single nutrient in a chemostat. Each species promotes the growth of the other, and growth occurs only in the presence of…

动力系统 · 数学 2026-03-12 Tahani Mtar , Radhouane Fekih-Salem

In living cells, chemical reactions form a complex network. Complicated dynamics arising from such networks are the origins of biological functions. We propose a novel mathematical method to analyze bifurcation behaviors of a reaction…

分子网络 · 定量生物学 2018-08-08 Takashi Okada , Je-Chiang Tsai , Atsushi Mochizuki

This research investigates the coupled dynamics of behavior and infectious disease using a mathematical model. We integrate a two-state q-voter opinion process with SIS-type infection dynamics, where transmission rates are influenced by the…

物理与社会 · 物理学 2025-12-13 Thomas Goetz , Tyll Krueger , Karol Niedzielewski , Jan Schneider , Barbara Pabjan

Dynamical systems are used to model a variety of phenomena in which the bifurcation structure is a fundamental characteristic. Here we propose a statistical machine-learning approach to derive lowdimensional models that automatically…

定量方法 · 定量生物学 2015-06-11 Yohei Kondo , Kunihiko Kaneko , Shuji Ishihara

Experimental observations of an almost symmetric electronic circuit show complicated sequences of bifurcations. These results are discussed in the light of a theory of imperfect global bifurcations. It is shown that much of the dynamics…

混沌动力学 · 物理学 2009-11-07 Paul Glendinning , Jan Abshagen , Tom Mullin

This paper investigates the different behaviors of the process equation and parameters of their occurrences. The process equation is a multistable one dimensional map with nonlinear feedback and can show various behaviors such as period…

We investigate the bifurcation structure of equilibria in a class of non-autonomous ordinary differential equations governed by a season length parameter, $\tau$, which determines the alternation between growth and decline dynamics. This…

动力系统 · 数学 2025-07-09 Gonzalo Galiano , Julián Velasco