相关论文: Three Scale Unfolding Homogenization Method Applie…

In this contribution we present the first formulation of a heterogeneous multiscale method for an incompressible immiscible two-phase flow system with degenerate permeabilities. The method is in a general formulation which includes…

In this paper, we propose a multicontinuum homogenization approach for nonlinear problems involving dynamically evolving multiscale media. The main idea of the proposed approach is that one of the fine-scale variables defines continua. It…

For microscale heterogeneous PDEs, this article further develops novel theory and methodology for their macroscale mathematical/asymptotic homogenization. This article specifically encompasses the case of quasi-periodic heterogeneity with…

Numerical simulations for flow and transport in subsurface porous media often prove computationally prohibitive due to property data availability at multiple spatial scales that can vary by orders of magnitude. A number of model order…

The complexity and heterogeneity of bone tissue require a multiscale modelling to understand its mechanical behaviour and its remodelling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based…

We study homogenization of a locally periodic two-scale dual-continuum system where each continuum interacts with the other. Equations for each continuum are written separately with interaction terms (exchange terms) added. The…

We rigorously determine the scale-independent short range elastic parameters in the relaxed micromorphic generalized continuum model for a given periodic microstructure. This is done using both classical periodic homogenization and a new…

Asymptotic homogenisation is used to systematically derive reduced-order macroscopic models of conductive behaviour in spirally-wound layered materials in which the layers have very different conductivities. The problem is motivated by the…

A reduced model, which can fold both helix and sheet structures, is proposed to study the problem of protein folding. The goal of this model is to find an unbiased effective potential that has included the effects of water and at the same…

The homogenization of auxetic cellular solids having periodic hexachiral and tetrachiral microstructure is dealt with two different techniques. The first approach is based on the representation of the cellular solid as a beam-lattice to be…

Research in cell biology is steadily contributing new knowledge about many different aspects of physiological processes like polymerization, both with respect to the involved molecular structures as well as their related function.…

We aim to understand the formation of abnormal waves of activity from myocardial regions with diminished cell-to-cell coupling. In route to this goal, we studied the behavior of a heterogeneous myocyte network in which a sharp coupling…

Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D aggregate cultures used in manufacturing exhibit substantial…

We develop a family of expanded mixed Multiscale Finite Element Methods (MsFEMs) and their hybridizations for second-order elliptic equations. This formulation expands the standard mixed Multiscale Finite Element formulation in the sense…

We study the asymptotic behaviour of a system of nonlinear reaction--diffusion--advection equations in a domain consisting of two bulk regions connected via microscopic channels distributed within a thin membrane. Both the width of the…

We propose a hemodynamic reduced-order model bridging macroscopic and meso-scopic blood flow circulation scales from arteries to capillaries. In silico tree like vascular geometries, mathematically described by graphs, are synthetically…

A coupled cell system is an ODE system associated with a coupled cell network, where the dimension is determined by the number of cells. A heteroclinic connection is a set of solution trajectories between two equilibria of an ODE system. A…

We carried out three-dimensional simulations, with about 1.4 million particles, of phase segregation in a low density binary fluid mixture, described mesoscopically by energy and momentum conserving Boltzmann-Vlasov equations. Using a…

A multifield asymptotic homogenization technique for periodic thermo-diffusive elastic materials is provided in the present study. Field equations for the first-order equivalent medium are derived and overall constitutive tensors are…

The paper addresses the homogenization of a micro-model of poroelasticity coupled with thermal effects for two-constituent media and with imperfect interfacial contact.The homogenized model is obtained by means of the two-scale convergence…