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This paper presents an efficient finite element iterative method for solving a nonuniform size-modified Poisson-Nernst-Planck ion channel (SMPNPIC) model, along with a SMPNPIC program package that works for an ion channel protein with a…

数值分析 · 数学 2024-05-06 Dexuan Xie

The analysis of structure-preserving numerical methods for the Poisson--Nernst--Planck (PNP) system has attracted growing interests in recent years. In this work, we provide an optimal rate convergence analysis and error estimate for finite…

数值分析 · 数学 2022-02-23 Jie Ding , Cheng Wang , Shenggao Zhou

In this paper, a nonuniform size modified Poisson-Boltzmann ion channel (nuSMPBIC) model is presented as a nonlinear system of an electrostatic potential and multiple ionic concentrations. It mixes nonlinear algebraic equations with a…

数值分析 · 数学 2022-09-14 Dexuan Xie

In this article, we propose and analyze a fully coupled, nonlinear, and energy-stable virtual element method (VEM) for solving the coupled Poisson-Nernst-Planck (PNP) and Navier--Stokes (NS) equations modeling microfluidic and…

数值分析 · 数学 2023-06-27 Mehdi Dehghan , Zeinab Gharibi , Ricardo Ruiz-Baier

The Poisson-Nernst-Planck equations with generalized Frumkin-Butler-Volmer boundary conditions (PNP-FBV) describe ion transport with Faradaic reactions and have applications in a wide variety of fields. Using an adaptive time-stepper based…

数值分析 · 数学 2020-06-24 M. C. Pugh , D. Yan , F. P. Dawson

We present a 3D finite element solver for the nonlinear Poisson-Nernst-Planck (PNP) equations for electrodiffusion, coupled to the Stokes system of fluid dynamics. The model serves as a building block for the simulation of macromolecule…

A macroscopic model to describe the dynamics of ion transport in ion channels is the Poisson-Nernst-Planck(PNP) equations. In this paper, we develop a finite-difference method for solving PNP equations, which is second-order accurate in…

数值分析 · 数学 2013-03-18 Allen Flavell , Michael Machen , Bob Eisenberg , Chun Liu , Xiaofan Li

We develop an efficient and reliable adaptive finite element method (AFEM) for the nonlinear Poisson-Boltzmann equation (PBE). We first examine the regularization technique of Chen, Holst, and Xu; this technique made possible the first a…

数值分析 · 数学 2010-10-01 Michael Holst , James Andrew McCammon , Zeyun Yu , Yongcheng Zhou , Yunrong Zhu

In this article we study adaptive finite element methods (AFEM) with inexact solvers for a class of semilinear elliptic interface problems. We are particularly interested in nonlinear problems with discontinuous diffusion coefficients, such…

数值分析 · 数学 2016-08-24 Michael Holst , Ryan Szypowski , Yunrong Zhu

This work presents a finite element method for a modified Poisson-Nernst-Planck/Navier-Stokes (PNP/NS) model under the mechanical equilibrium, developed for compressible electrolytes. Another key contribution of this work is the reduction…

数值分析 · 数学 2026-01-27 Ankur , Ram Jiwari , Satyvir Singh

Numerical methods are proposed for an advanced Poisson-Nernst-Planck-Fermi (PNPF) model for studying ion transport through biological ion channels. PNPF contains many more correlations than most models and simulations of channels, because…

生物大分子 · 定量生物学 2015-06-22 Jinn-Liang Liu , Bob Eisenberg

An artificial intelligence-augmented Streamline Upwind/Petrov-Galerkin finite element scheme (AiStab-FEM) is proposed for solving singularly perturbed partial differential equations. In particular, an artificial neural network framework is…

偏微分方程分析 · 数学 2022-11-28 Sangeeta Yadav , Sashikumaar Ganesan

The Intrinsic Surface Finite Element Method (ISFEM) was recently proposed to solve Partial Differential Equations (PDEs) on surfaces. ISFEM proceeds by writing the PDE with respect to a local coordinate system anchored to the surface and…

数值分析 · 数学 2024-10-08 Elena Bachini , Mario Putti

Ion transport, often described by the Poisson--Nernst--Planck (PNP) equations, is ubiquitous in electrochemical devices and many biological processes of significance. In this work, we develop conservative, positivity-preserving, energy…

数值分析 · 数学 2020-07-15 Jie Ding , Zhongming Wang , Shenggao Zhou

The Poisson--Nernst--Planck (PNP) equations have been widely applied to describe ionic transport in ion channels, nanofluidic devices, and many electrochemical systems. Despite their wide applications, the PNP equations fail in predicting…

统计力学 · 物理学 2018-01-03 Farjana Siddiqua , Zhongming Wang , Shenggao Zhou

The Poisson-Nernst-Planck (PNP) equations are one of the most effective model for describing electrostatic interactions and diffusion processes in ion solution systems, and have been widely used in the numerical simulations of biological…

数值分析 · 数学 2023-12-19 Yang Liu , Shi Shu , Ying Yang

The recently proposed statistical finite element (statFEM) approach synthesises measurement data with finite element models and allows for making predictions about the unknown true system response. We provide a probabilistic error analysis…

统计理论 · 数学 2025-06-17 Toni Karvonen , Fehmi Cirak , Mark Girolami

When using the finite element method (FEM) in inverse problems, its discretization error can produce parameter estimates that are inaccurate and overconfident. The Bayesian finite element method (BFEM) provides a probabilistic model for the…

数值分析 · 数学 2026-01-26 Anne Poot , Iuri Rocha , Pierre Kerfriden , Frans van der Meer

The Poisson-Nernst-Planck (PNP) equations are fundamental for modeling ion transport in electrochemical systems, capturing the intricate interplay of concentration gradients, electric fields, and ion fluxes essential for applications such…

化学物理 · 物理学 2025-01-13 Yitao He , Dan Zhao

Effective Poisson-Nernst-Planck (PNP) equations are derived for macroscopic ion transport in charged porous media under periodic fluid flow by an asymptotic multi-scale expansion with drift. The microscopic setting is a two-component…

数学物理 · 物理学 2014-07-16 Markus Schmuck , Martin Z. Bazant
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