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We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a…

种群与进化 · 定量生物学 2022-07-08 Martina Favero , Gianpaolo Scalia Tomba , Tom Britton

Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in ECG morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of…

生物物理 · 物理学 2009-11-13 Xiaopeng Zhao

We have developed a coarse-grained formulation for modeling the dynamic behavior of cells quantitatively, based on stochasticity and heterogeneity, rather than on biochemical reactions. We treat each reaction as a continuous-time stochastic…

分子网络 · 定量生物学 2015-05-28 Shunsuke Teraguchi , Yutaro Kumagai , Alexis Vandenbon , Shizuo Akira , Daron M Standley

We study a Kuramoto-like model of coupled identical phase oscillators on a network, where attractive and repulsive couplings are balanced dynamically due to nonlinearity in interaction. Under a week force, an oscillator tends to follow the…

适应与自组织系统 · 物理学 2015-01-28 Celso Freitas , Elbert Macau , Arkady Pikovsky

The mixture cure rate model is the most commonly used cure rate model in the literature. In the context of mixture cure rate model, the standard approach to model the effect of covariates on the cured or uncured probability is to use a…

统计方法学 · 统计学 2022-08-23 Suvra Pal , Yingwei Peng , Sandip Barui , Pei Wang

The tree-structured varying coefficient model (TSVC) is a flexible regression approach that allows the effects of covariates to vary with the values of the effect modifiers. Relevant effect modifiers are identified inherently using…

统计方法学 · 统计学 2024-07-01 Nikolai Spuck , Matthias Schmid , Malte Monin , Moritz Berger

We study the emergent dynamics of the singular continuum Kuramoto model (in short, SCKM) and its graph limit. The SCKM takes the form of an integro-differential equation exhibiting two types of nonlocal singularities: a nonlocal singular…

动力系统 · 数学 2026-05-11 Li Chen , Seung-Yeal Ha , Xinyu Wang , Valeriia Zhidkova

Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber…

偏微分方程分析 · 数学 2008-12-04 Christian Bourdarias , Stéphane Gerbi , Jacques Ohayon

Various macroscopic oscillations, such as the heartbeat and the flashing of fireflies, are created by synchronizing oscillatory units (oscillators). To elucidate the mechanism of synchronization, several coupled oscillator models have been…

数据分析、统计与概率 · 物理学 2025-07-01 Yusuke Kato , Shuhei Kashiwamura , Emiri Watanabe , Masato Okada , Hiroshi Kori

We propose a novel inverse method that utilizes a set of data to construct a simple equation that governs the stochastic process for which the data have been measured, hence enabling us to reconstruct the stochastic process. As an example,…

统计力学 · 物理学 2007-05-23 J. Peinke , M. Reza Rahimi Tabar , Muhammad Sahimi , F. Ghasemi

We introduce a novel Bayesian approach for jointly modeling longitudinal cardiovascular disease (CVD) risk factor trajectories, medication use, and time-to-events. Our methodology incorporates longitudinal risk factor trajectories into the…

统计方法学 · 统计学 2025-03-25 Zeynab Aghabazaz , Michael J Daniels , Donald M Lloyd-Jones , Juned Siddique

These notes describe stochastic epidemics in a homogenous community. Our main concern is stochastic compartmental models (i.e. models where each individual belongs to a compartment, which stands for its status regarding the epidemic under…

概率论 · 数学 2020-02-06 Tom Britton , Etienne Pardoux

In this article we mainly extend the deterministic model developed in [10] to a stochastic setting. More precisely, we incorporated randomness in some coefficients by assuming that they follow a prescribed stochastic dynamics. In this way,…

数值分析 · 数学 2020-10-30 Álvaro Leitao , Carlos Vázquez

The dynamics of cellular chemical reactions are variable due to stochastic noise from intrinsic and extrinsic sources. The intrinsic noise is the intracellular fluctuations of molecular copy numbers caused by the probabilistic encounter of…

系统与控制 · 电气工程与系统科学 2023-01-13 Yuta Sakurai , Yutaka Hori

Two stochastic models are proposed to describe the evolution of the COVID-19 pandemic. In the first model the population is partitioned into four compartments: susceptible $S$, infected $I$, removed $R$ and dead people $D$. In order to have…

种群与进化 · 定量生物学 2021-09-16 Fabiana Calleri , Giovanni Nastasi , Vittorio Romano

The Vicsek model for the self-propelled particles is investigated with the respect to the introduction of the stochastic perturbation of the dynamics. It is shown that such a dependence can be thought in terms of the isomorphism of the…

统计力学 · 物理学 2010-11-11 A. A. Chepizhko , V. L. Kulinskii

A self-consistent equation to derive a discreteness-induced stochastic steady state is presented for reaction-diffusion systems. For this formalism, we use the so-called Kuramoto length, a typical distance over which a molecule diffuses in…

化学物理 · 物理学 2007-05-23 Yuichi Togashi , Kunihiko Kaneko

We consider a generational and continuous-time two-phase model of the cell cycle. The first model is given by a stochastic operator, and the second by a piecewise deterministic Markov process. In the second case we also introduce a…

概率论 · 数学 2018-07-30 Katarzyna Pichór , Ryszard Rudnicki

An enviromental-random effect over a deterministic population mo\-del, a resource ({\it e.g.}, a fish stock) is introduced. It is assumed that the harvest activity is concentrated at a non predetermined sequence of instants, at which the…

概率论 · 数学 2014-07-01 Ricardo Castro-Santis , Fernado Cordova , Walter Chambio

Ensembles of phase-oscillators are known to exhibit a variety of collective regimes. Here, we show that a simple mean-field model involving two heterogenous populations of pulse-coupled oscillators, exhibits, in the strong-coupling limit, a…

无序系统与神经网络 · 物理学 2024-07-12 German Mato , Antonio Politi , Alessandro Torcini