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We consider a single outbreak susceptible-infected-recovered (SIR) model and corresponding estimation procedures for the effective reproductive number $\mathcal{R}(t)$. We discuss the estimation of the underlying SIR parameters with a…

种群与进化 · 定量生物学 2020-04-16 Ariel Cintrón-Arias , Carlos Castillo-Chávez , Luís M. A. Bettencourt , Alun L. Lloyd , H. T. Banks

Spectral measures arise in numerous applications such as quantum mechanics, signal processing, resonances, and fluid stability. Similarly, spectral decompositions (pure point, absolutely continuous and singular continuous) often…

谱理论 · 数学 2021-03-02 Matthew John Colbrook

We consider a size-structured model for cell division and address the question of determining the division (birth) rate from the measured stable size distribution of the population. We propose a new regularization technique based on a…

数值分析 · 数学 2013-01-21 Marie Doumic Jauffret , Benoît Perthame , Jorge P. Zubelli

In an extant population, how much information do extant individuals provide on the pedigree of their ancestors? Recent work by Kim, Mossel, Ramnarayan and Turner (2020) studied this question under a number of simplifying assumptions,…

种群与进化 · 定量生物学 2022-11-29 Elchanan Mossel , David Vulakh

Branching process inspired models are widely used to estimate the effective reproduction number -- a useful summary statistic describing an infectious disease outbreak -- using counts of new cases. Case data is a real-time indicator of…

统计方法学 · 统计学 2023-10-03 Isaac H. Goldstein , Jon Wakefield , Volodymyr M. Minin

For birth-and-death processes, we show that every initial distribution is reproduced from the first hitting time distribution. The reproduction is done by applying to the distribution function a differential operator defined through the…

概率论 · 数学 2022-03-24 Kosuke Yamato , Kouji Yano

It is essential to understand the dynamics of epidemics in the presence of coexisting pathogens. There are various phenomenon that can effect the dynamics. In this paper, we formulate a mathematical model using different assumptions to…

种群与进化 · 定量生物学 2021-11-02 S. Ghersheen , V. Kozlov , U. Wennergren

We discuss the generation of various reproduction ratios or numbers that are very useful to monitor an ongoing epidemic like Covid-19 and examine the effects of intervention measures. A detailed SEIR algorithm is described for their…

种群与进化 · 定量生物学 2020-06-25 Paulo R. Zingano , Janaina P. Zingano , Alessandra M. Silva , Carolina P. Zingano

A class of multiple-timescale asymptotic solutions to the equations of the susceptible-infected-recovered (SIR) model is presented for the case of high basic reproduction number, with the inverse of the latter employed as the expansion…

种群与进化 · 定量生物学 2025-12-25 Oleg B. Shiryaev

In spectral clustering, one defines a similarity matrix for a collection of data points, transforms the matrix to get the Laplacian matrix, finds the eigenvectors of the Laplacian matrix, and obtains a partition of the data using the…

机器学习 · 计算机科学 2012-10-19 Leonard K. M. Poon , April H. Liu , Tengfei Liu , Nevin Lianwen Zhang

This paper analyzes the statistical performance of a robust spectral clustering method for latent structure recovery in noisy data matrices. We consider eigenvector-based clustering applied to a matrix of nonparametric rank statistics that…

机器学习 · 统计学 2024-12-23 Joshua Cape , Xianshi Yu , Jonquil Z. Liao

We propose a second-order accurate method to estimate the eigenvectors of extremely large matrices thereby addressing a problem of relevance to statisticians working in the analysis of very large datasets. More specifically, we show that…

数值分析 · 数学 2010-02-05 Noureddine El Karoui , Alexandre d'Aspremont

We review the problem of how to compute the spectral density of sparse symmetric random matrices, i.e. weighted adjacency matrices of undirected graphs. Starting from the Edwards-Jones formula, we illustrate the milestones of this line of…

统计力学 · 物理学 2021-08-11 Vito A R Susca , Pierpaolo Vivo , Reimer Kühn

We study a birth and death model for the adapatation of a sexual population to an environment. The population is structured by a phenotypical trait, and, possibly, an age variable. Recombination is modeled by Fisher's infinitesimal…

种群与进化 · 定量生物学 2017-03-28 Thibault Bourgeron , Vincent Calvez , Jimmy Garnier , Thomas Lepoutre

We study the mathematical properties of a general model of cell division structured with several internal variables. We begin with a simpler and specific model with two variables, we solve the eigenvalue problem with strong or weak…

偏微分方程分析 · 数学 2008-10-08 Marie Doumic Jauffret

We consider the spectral analysis of several examples of bilateral birth-death processes and compute explicitly the spectral matrix and the corresponding orthogonal polynomials. We also use the spectral representation to study some…

概率论 · 数学 2021-06-01 Manuel D. de la Iglesia

The duration, type and structure of connections between individuals in real-world populations play a crucial role in how diseases invade and spread. Here, we incorporate the aforementioned heterogeneities into a model by considering a…

物理与社会 · 物理学 2018-04-05 Rosanna C Barnard , Istvan Z Kiss , Luc Berthouze , Joel C Miller

This paper offers a review of numerical methods for computation of the eigenvalues of Hermitian matrices and the singular values of general and some classes of structured matrices. The focus is on the main principles behind the methods that…

数值分析 · 数学 2020-06-05 Zlatko Drmač

The time-dependent reproduction number Rt can be used to track pathogen transmission and to assess the efficacy of interventions. This quantity can be estimated by fitting renewal equation models to time series of infectious disease case…

种群与进化 · 定量生物学 2025-01-30 Ioana Bouros , Robin Thompson , David Gavaghan , Ben Lambert

We consider the spectrum of birth and death chains on a $n$-path. An iterative scheme is proposed to compute any eigenvalue with exponential convergence rate independent of $n$. This allows one to determine the whole spectrum in order $n^2$…

概率论 · 数学 2013-05-03 Guan-Yu Chen , Laurent Saloff-Coste