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Relationships of cause and effect are of prime importance for explaining scientific phenomena. Often, rather than just understanding the effects of causes, researchers also wish to understand how a cause $X$ affects an outcome $Y$…

统计方法学 · 统计学 2024-11-14 Drago Plecko

An important problem in causal inference is to break down the total effect of a treatment on an outcome into different causal pathways and to quantify the causal effect in each pathway. For instance, in causal fairness, the total effect of…

机器学习 · 统计学 2022-01-10 Lu Cheng , Ruocheng Guo , Huan Liu

In randomized trials, once the total effect of the intervention has been estimated, it is often of interest to explore mechanistic effects through mediators along the causal pathway between the randomized treatment and the outcome. In the…

统计方法学 · 统计学 2021-12-28 Erin E Gabriel , Michael C Sachs , Arvid Sjölander

A parametric expression for causal natural direct and indirect effects is derived for the setting of a binary outcome with a binary mediator. The proposed effect decomposition does not require the outcome to be rare and generalizes the…

统计方法学 · 统计学 2021-04-13 Marco Doretti , Martina Raggi , Elena Stanghellini

Consider the case where cause-effect relationships between variables can be described as a directed acyclic graph and the corresponding linear structural equation model. This paper provides graphical identifiability criteria for total…

统计方法学 · 统计学 2012-07-09 Manabu Kuroki , Zhihong Cai , Hiroki Motogaito

The fundamental problem in treatment effect estimation from observational data is confounder identification and balancing. Most of the previous methods realized confounder balancing by treating all observed pre-treatment variables as…

统计方法学 · 统计学 2021-10-13 Anpeng Wu , Kun Kuang , Junkun Yuan , Bo Li , Runze Wu , Qiang Zhu , Yueting Zhuang , Fei Wu

Causal mediation analysis (CMA) is a powerful method to dissect the total effect of a treatment into direct and mediated effects within the potential outcome framework. This is important in many scientific applications to identify the…

机器学习 · 计算机科学 2023-06-14 Ziyang Jiang , Yiling Liu , Michael H. Klein , Ahmed Aloui , Yiman Ren , Keyu Li , Vahid Tarokh , David Carlson

This article extends the widely-used synthetic controls estimator for evaluating causal effects of policy changes to quantile functions. The proposed method provides a geometrically faithful estimate of the entire counterfactual quantile…

计量经济学 · 经济学 2022-01-03 Florian Gunsilius

While estimation of the marginal (total) causal effect of a point exposure on an outcome is arguably the most common objective of experimental and observational studies in the health and social sciences, in recent years, investigators have…

统计理论 · 数学 2012-10-18 Eric J. Tchetgen Tchetgen , Ilya Shpitser

The procedure for establishing mediation, i.e., determining that an independent variable X affects a dependent variable Y through some mediator M, has been under debate. The classic causal steps require that a "total effect" be significant,…

计量经济学 · 经济学 2023-09-26 Tingxuan Han , Luxi Zhang , Xinshu Zhao , Ke Deng

To investigate causal mechanisms, causal mediation analysis decomposes the total treatment effect into the natural direct and indirect effects. This paper examines the estimation of the direct and indirect effects in a general treatment…

统计理论 · 数学 2024-01-24 Lukang Huang , Wei Huang , Oliver Linton , Zheng Zhang

Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects. These…

统计方法学 · 统计学 2019-06-06 Johan Steen , Stijn Vansteelandt

Understanding causal mechanisms is crucial for explaining and generalizing empirical phenomena. Causal mediation analysis offers statistical techniques to quantify the mediation effects. Although numerous methods have been developed for…

统计方法学 · 统计学 2026-05-12 Jiawei Fu

Accurate estimation of counterfactual outcomes in high-dimensional data is crucial for decision-making and understanding causal relationships and intervention outcomes in various domains, including healthcare, economics, and social…

机器学习 · 计算机科学 2024-07-31 Jiageng Zhu , Hanchen Xie , Jiazhi Li , Wael Abd-Almageed

Causal mediation analysis is used to evaluate direct and indirect causal effects of a treatment on an outcome of interest through an intermediate variable or a mediator.It is difficult to identify the direct and indirect causal effects…

应用统计 · 统计学 2020-01-14 Wei Li , Chunchen Liu , Zhi Geng , John Murray

Path-specific effects in mediation analysis provide a useful tool for fairness analysis, which is mostly based on nested counterfactuals. However, the dictum ``no causation without manipulation'' implies that path-specific effects might be…

人工智能 · 计算机科学 2021-06-08 Heyang Gong , Ke Zhu

Mediation analyses play important roles in making causal inference in biomedical research to examine causal pathways that may be mediated by one or more intermediate variables (i.e., mediators). Although mediation frameworks have been well…

应用统计 · 统计学 2023-01-25 Meilin Jiang , Seonjoo Lee , James O'Malley , Yaakov Stern , Zhigang Li

A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the…

统计方法学 · 统计学 2023-08-31 Oliver Dukes , Ilya Shpitser , Eric J. Tchetgen Tchetgen

Interpretability research takes counterfactual theories of causality for granted. Most causal methods rely on counterfactual interventions to inputs or the activations of particular model components, followed by observations of the change…

机器学习 · 计算机科学 2024-07-08 Aaron Mueller

Mediation analysis is widely used for investigating direct and indirect causal pathways through which an effect arises. However, many mediation analysis studies are challenged by missingness in the mediator and outcome. In general, when the…

统计方法学 · 统计学 2023-09-25 Shuozhi Zuo , Debashis Ghosh , Peng Ding , Fan Yang