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This paper provides robust estimators and efficient inference of causal effects involving multiple interacting mediators. Most existing works either impose a linear model assumption among the mediators or are restricted to handle…

统计方法学 · 统计学 2024-01-12 Haoyu Wei , Hengrui Cai , Chengchun Shi , Rui Song

There have been numerous publications on the advantages and disadvantages of estimating natural (pure) effects compared to controlled effects. One of the main criticisms of natural effects is that it requires an additional assumption for…

统计方法学 · 统计学 2024-03-01 Ian Shrier

With multiple potential mediators on the causal pathway from a treatment to an outcome, we consider the problem of decomposing the effects along multiple possible causal path(s) through each distinct mediator. Under Pearl's path-specific…

统计方法学 · 统计学 2021-02-04 Wen Wei Loh , Beatrijs Moerkerke , Tom Loeys , Stijn Vansteelandt

Classical causal inference assumes treatments meant for a given unit do not have an effect on other units. This assumption is violated in interference problems, where new types of spillover causal effects arise, and causal inference becomes…

统计方法学 · 统计学 2024-09-30 Ilya Shpitser , Chan Park , Eric Tchetgen Tchetgen , Ryan Andrews

Conventional research on educational effects typically either employs a "years of schooling" measure of education, or dichotomizes attainment as a point-in-time treatment. Yet, such a conceptualization of education is misaligned with the…

应用统计 · 统计学 2026-02-11 Aleksei Opacic

Global feature effect methods, such as partial dependence plots, provide an intelligible visualization of the expected marginal feature effect. However, such global feature effect methods can be misleading, as they do not represent local…

机器学习 · 统计学 2024-12-18 Julia Herbinger , Marvin N. Wright , Thomas Nagler , Bernd Bischl , Giuseppe Casalicchio

Semi-competing risks refer to the phenomenon that the terminal event (such as death) can censor the non-terminal event (such as disease progression) but not vice versa. The treatment effect on the terminal event can be delivered either…

统计方法学 · 统计学 2024-10-10 Yuhao Deng , Yi Wang , Xiao-Hua Zhou

Decomposing an exposure effect on an outcome into separate natural indirect effects through multiple mediators requires strict assumptions, such as correctly postulating the causal structure of the mediators, and no unmeasured confounding…

统计方法学 · 统计学 2021-02-04 Wen Wei Loh , Beatrijs Moerkerke , Tom Loeys , Stijn Vansteelandt

Estimating causal effects is vital for decision making. In standard causal effect estimation, treatments are usually binary- or continuous-valued. However, in many important real-world settings, treatments can be structured,…

Estimating an individual's potential outcomes under counterfactual treatments is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, impulse…

Causal mediation analysis is an important statistical method in social and medical studies, as it can provide insights about why an intervention works and inform the development of future interventions. Currently, most causal mediation…

统计方法学 · 统计学 2016-01-26 Cheng Zheng , David C. Atkins , Melissa A. Lewis , Xiao-Hua Zhou

Analyses of causal mediation often involve exposure-induced confounders or, relatedly, multiple mediators. In such applications, researchers aim to estimate a variety of different quantities, including interventional direct and indirect…

统计方法学 · 统计学 2025-06-18 Jesse Zhou , Geoffrey T. Wodtke

Causal mediation analysis is a useful tool for epidemiological research, but it has been criticized for relying on a "cross-world" independence assumption that is empirically difficult to verify and problematic to justify based on…

统计方法学 · 统计学 2021-09-02 Ryan M. Andrews , Vanessa Didelez

Mediation analysis breaks down the causal effect of a treatment on an outcome into an indirect effect, acting through a third group of variables called mediators, and a direct effect, operating through other mechanisms. Mediation analysis…

应用统计 · 统计学 2025-05-13 Judith Abécassis , Houssam Zenati , Sami Boumaïza , Julie Josse , Bertrand Thirion

Decomposing a total causal effect into natural direct and indirect effects is central to revealing causal mechanisms. Conventional methods achieve the decomposition by specifying an outcome model as a linear function of the treatment, the…

统计方法学 · 统计学 2025-06-05 Guanglei Hong

Mediation analysis is difficult when the number of potential mediators is larger than the sample size. In this paper we propose new inference procedures for the indirect effect in the presence of high-dimensional mediators for linear…

统计方法学 · 统计学 2019-10-29 Ruixuan Rachel Zhou , Liewei Wang , Sihai Dave Zhao

Estimating individual-level treatment effect from observational data is a fundamental problem in causal inference and has attracted increasing attention in the fields of education, healthcare, and public policy.In this work, we concentrate…

机器学习 · 计算机科学 2025-07-10 Hui Meng , Keping Yang , Xuyu Peng , Bo Zheng

Counterfactuals -- expressing what might have been true under different circumstances -- have been widely applied in statistics and machine learning to help understand causal relationships. More recently, counterfactuals have begun to…

人机交互 · 计算机科学 2024-04-08 Arran Zeyu Wang , David Borland , David Gotz

Causal mediation analysis is widely used to investigate how causal effects operate through specific pathways linking treatments or exposures to outcomes. Recently, \texttt{crumble} was developed to enable nonparametric estimation of several…

统计方法学 · 统计学 2026-04-14 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Ivan Diaz

This paper introduces a novel decomposition framework to explain heterogeneity in causal effects observed across different studies, considering both observational and randomized settings. We present a formal decomposition of between-study…

统计方法学 · 统计学 2025-12-18 Brian Gilbert , Ivan Dıaz , Kara E. Rudolph , Nicholas Williams , Tat-Thang Vo