相关论文: SOS: Online probability estimation and generation …
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These…
High throughput immune repertoire sequencing is promising to lead to new statistical diagnostic tools for medicine and biology. Successful implementations of these methods require a correct characterization, analysis and interpretation of…
The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ recombination, and selection based on the recognition of random self-peptides presented…
Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains…
Reanalysis data, such as ERA5, provide a comprehensive and detailed representation of the Earth's system by assimilating observations into climate models. While crucial for climate research, they pose significant challenges in terms of…
Online Social Networks (OSNs) have witnessed a tremendous growth the last few years, becoming a platform for online users to communicate, exchange content and even find employment. The emergence of OSNs has attracted researchers and…
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the…
We propose an approach for Open-World Instance Segmentation (OWIS), a task that aims to segment arbitrary unknown objects in images by generalizing from a limited set of annotated object classes during training. Our Segment Object System…
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ…
The difficulty of processing gigapixel whole slide images (WSIs) in clinical microscopy has been a long-standing barrier to implementing computer aided diagnostic systems. Since modern computing resources are unable to perform computations…
Discrete-event simulation (DES) is widely used in healthcare Operations Research, but the models themselves are rarely shared. This limits their potential for reuse and long-term impact in the modelling and healthcare communities. This…
Smart Reply (SR) systems present a user with a set of replies, of which one can be selected in place of having to type out a response. To perform well at this task, a system should be able to effectively present the user with a diverse set…
Subsampling is an effective approach to alleviate the computational burden associated with large-scale datasets. Nevertheless, existing subsampling estimators incur a substantial loss in estimation efficiency compared to estimators based on…
The integration of converter-interfaced generation (CIG) from renewable energy sources poses challenges to the stability and transient behavior of electric power systems. Understanding the dynamic behavior of low-inertia power systems is…
This paper addresses the modelling of requirements for a content Recommendation System (RS) for Online Social Networks (OSNs). On OSNs, a user switches roles constantly between content generator and content receiver. The goals and softgoals…
Recent state-of-the-art one-stage instance segmentation model SOLO divides the input image into a grid and directly predicts per grid cell object masks with fully-convolutional networks, yielding comparably good performance as traditional…
Neural text generation models are likely to suffer from the low-diversity problem. Various decoding strategies and training-based methods have been proposed to promote diversity only by exploiting contextual features, but rarely do they…
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and malignancies. Modeling the distribution of TCR sequences is of…
Asterias (\url{http://www.asterias.info}) is an integrated collection of freely-accessible web tools for the analysis of gene expression and aCGH data. Most of the tools use parallel computing (via MPI). Most of our applications allow the…
We create the first large-scale mock spectroscopic survey of gas absorption sightlines traversing the interstellar medium (ISM), circumgalactic medium (CGM), and intergalactic medium (IGM) surrounding galaxies of virtual Universes. That is,…