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The work presents the analysis of the free boundary value problem related to the invasion model of new species in biofilm reactors. In the framework of continuum approach to mathematical modelling of biofilm growth, the problem consists of…

生物物理 · 物理学 2021-04-09 Berardino D'Acunto , Luigi Frunzo , Vincenzo Luongo , Maria Rosaria Mattei

Biofilms are complex structures which are inhabited by numerous amount of different species of microorganisms. Due to their ubiquity, they influence human life on an everyday basis. It is therefore important to understand the interactions…

计算工程、金融与科学 · 计算机科学 2025-09-03 Felix Klempt , Hendrik Geisler , Meisam Soleimani , Philipp Junker

We analyze the mathematical properties of a multi-species biofilm cross-diffusion model together with very general reaction terms and mixed Dirichlet-Neumann boundary conditions on a bounded domain. This model belongs to the class of…

偏微分方程分析 · 数学 2018-05-08 Esther S. Daus , Josipa-Pina Milišić , Nicola Zamponi

This work presents the existence and uniqueness of solution to a free boundary value problem related to biofilm growth. The problem consists of a system of nonlinear hyperbolic partial differential equations governing the microbial species…

偏微分方程分析 · 数学 2025-03-26 Dieudonné Zirhumanana Balike , Luigi Frunzo , Maria Rosaria Mattei , Fabiana Russo

The dynamics of biofilm lifecycle are deeply influenced by the surrounding environment and the interactions between sessile and planktonic phenotypes. Bacterial biofilms typically develop in three distinct stages: attachment of cells to a…

偏微分方程分析 · 数学 2021-07-07 B. D'Acunto , L. Frunzo , V. Luongo , M. R. Mattei , A. Tenore

A free boundary value problem related to the genesis of multispecies granular biofilms is presented. The granular biofilm is modelled as a spherical free boundary domain with radial symmetry. The proposed model is conceived in the framework…

偏微分方程分析 · 数学 2023-01-31 F. Russo , M. R. Mattei , A. Tenore , B. D'Acunto , V. Luongo , L. Frunzo

In this paper, we derive upscaled equations for modelling biofilm growth in porous media. The resulting macro-scale mathematical models consider permeable multi-species biofilm including water flow, transport, detachment and reactions. The…

流体动力学 · 物理学 2020-07-14 David Landa-Marbán , Gunhild Bødtker , Kundan Kumar , Iuliu Sorin Pop , Florin Adrian Radu

We perform mathematical anaysis of the biofilm development process. A model describing biomass growth is proposed: It arises from coupling three parabolic nonlinear equations: a biomass equation with degenerate and singular diffusion, a…

偏微分方程分析 · 数学 2017-03-14 Maria Gokieli , Nobuyuki Kenmochi , Marek Niezgódka

In this paper we derive a pore-scale model for permeable biofilm formation in a two-dimensional pore. The pore is divided in two phases: water and biofilm. The biofilm is assumed to consist of four components: water, extracellular polymeric…

An implicit Euler finite-volume scheme for a parabolic reaction-diffusion system modeling biofilm growth is analyzed and implemented. The system consists of a degenerate-singular diffusion equation for the biomass fraction, which is coupled…

数值分析 · 数学 2021-10-29 Christoph Helmer , Ansgar Jüngel , Antoine Zurek

We propose a modeling approach to study how mature biofilms spread and colonize new surfaces by predicting the formation and growth of satellite colonies generated by dispersing biofilms. This model provides the basis for better…

生物物理 · 物理学 2017-12-14 Andrea Trucchia , Federica Villa , Luigi Frunzo , Gianni Pagnini

A dissipative particle dynamics (DPD) model for the quantitative simulation of biofilm growth controlled by substrate (nutrient) consumption, advective and diffusive substrate transport, and hydrodynamic interactions with fluid flow…

计算物理 · 物理学 2018-08-03 Zhijie Xu , Paul Meakin , Alexandre Tartakovsky , Timothy. D. Scheibe

In this paper we consider a system of two coupled nonlinear diffusion--reaction partial differential equations (PDEs) which model the growth of biofilm and consumption of the nutrient. At the scale of interest the biofilm density is subject…

数值分析 · 数学 2020-01-03 Azhar Alhammali , Malgorzata Peszynska

We propose a model of antibiotic diffusion through a bacterial biofilm when diffusion and/or absorption barriers develop in the biofilm. The idea of this model is: We deduce details of the diffusion process in a medium in which direct…

生物物理 · 物理学 2020-09-23 Tadeusz Kosztołowicz , Ralf Metzler

Free boundaries of biofilms advancing on surfaces evolve according to conservation laws coupled with systems of partial differential equations for velocities, pressures and chemicals affecting cell behavior. Thin film approximations lead to…

偏微分方程分析 · 数学 2024-03-18 Ana Carpio , Gema Duro

Two phase solid-fluid mixture models are ubiquitous in biological applications. For instance, models for growth of tissues and biofilms combine time dependent and quasi-stationary boundary value problems set in domains whose boundary moves…

偏微分方程分析 · 数学 2024-01-17 Ana Carpio , Gema Duro

Biofilm infections on medical implants are difficult to eradicate because insufficient nutrient availability promotes antibiotic-tolerant persister cells that survive treatment and reseed growth. Existing mathematical models usually omit…

种群与进化 · 定量生物学 2025-09-23 Parna Mandal , Nigel J. Mottram , Sean McGinty

In this paper a reduced one-dimensional moving boundary model is studied that describes the evolution of a biofilm driven by the presence of a reaction limiting substrate. Global well-posedness is established for the resulting parabolic…

偏微分方程分析 · 数学 2025-05-30 Patrick Guidotti , Christoph Walker

A multiscale mathematical model describing the genesis and ecology of algal-bacterial photogranules and the metals biosorption on their solid matrix within a sequencing batch reactor (SBR) is presented. The granular biofilm is modelled as a…

细胞行为 · 定量生物学 2023-01-31 F. Russo , A. Tenore , M. R. Mattei , L. Frunzo

We develop a mathematical model for adsorption based on averaging the flow around, and diffusion inside, adsorbent particles in a column. The model involves three coupled partial differential equations for the contaminant concentration both…

其他凝聚态物理 · 物理学 2023-11-20 Lucy C. Auton , Maria Aguareles , Abel Valverde , Timothy G. Myers , Marc Calvo-Schwarzwalder
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