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A four-dimensional mathematical model of the hypothalamus-pituitary-adrenal (HPA) axis is investigated, incorporating the influence of the GR concentration and general feedback functions. The inclusion of distributed time delays provides a…

动力系统 · 数学 2018-12-26 Eva Kaslik , Mihaela Neamtu

This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and…

最优化与控制 · 数学 2017-01-31 Eva Kaslik , Dan Bogdan Navolan , Mihaela Neamtu

The memory-based diffusion systems have wide applications in practice. Hopf bifurcations are observed from such systems. To meet the demand for computing the normal forms of the Hopf bifurcations of such systems, we develop an effective new…

动力系统 · 数学 2021-04-02 Yongli Song , Yahong Peng , Tonghua Zhang

The hypothalamic pituitary adrenal (HPA) axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related…

动力系统 · 数学 2019-04-22 Casey Johnson , Roman M. Taranets , Natalia Vasylyeva , Marina Chugunova

A novel mathematical model for the hypothalamic pituitary adrenal (HPA) axis is proposed to comprehend the oscillations observed in hormone concentration and potential dysfunction within the HPA axis in stressful situation. This model…

动力系统 · 数学 2023-11-09 Imran Ahmad , Itishree Jena , A. Priyadarshi

In this paper, we consider a diffusive predator-prey system with spatial memory and predator-taxis. Since in this system, the memory delay appears in the diffusion term, and the diffusion term is nonlinear, the classical normal form of Hopf…

动力系统 · 数学 2022-01-11 Yehu Lv

In this paper, by incorporating the general delay to the reaction term in the memory-based diffusive system, we propose a diffusive system with memory delay and general delay (e.g., digestion, gestation, hunting, migration and maturation…

偏微分方程分析 · 数学 2022-03-22 Yehu Lv

We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell…

偏微分方程分析 · 数学 2009-04-17 Mostafa Adimy , Fabien Crauste , Shigui Ruan

The Hypothalamic-Pituitary-Adrenal (HPA) axis is a major neuroendocrine system, and its dysregulation is implicated in various diseases. This system also presents interesting mathematical challenges for modeling. We consider a nonlinear…

谱理论 · 数学 2024-12-03 Catherine Drysdale , Matthew J. Colbrook

Fractional derivative and delay are important tools in modeling memory properties in the natural system. This work deals with the stability analysis of a fractional order delay differential equation \begin{equation*} D^\alpha x(t)=\delta…

动力系统 · 数学 2022-08-29 Sachin Bhalekar , Deepa Gupta

The stability of functional differential equations under delayed feedback is investigated near a Hopf bifurcation. Necessary and sufficient conditions are derived for the stability of the equilibrium solution using averaging theory. The…

经典分析与常微分方程 · 数学 2008-12-31 Fatihcan M. Atay

We study the two state model which describes the balance equation for carbon dioxide and oxygen. These are nonlinear parameter dependent and because of the transport delay in the respiratory control system, they are modeled with delay…

动力系统 · 数学 2022-06-29 Nirjal Sapkota , Janos Turi

In this paper, we derive the algorithm for calculating the normal form of the double Hopf bifurcation that appears in a memory-based diffusion system via taking memory-based diffusion coefficient and the memory delay as the perturbation…

动力系统 · 数学 2022-02-10 Yongli Song , Yahong Peng , Tonghua Zhang

In this paper, we consider a continuous-time model with discrete and dis-tributed delays to describe how two pieces of information interact in online social networks. Sufficient conditions are carried out to illustrate the stability of each…

动力系统 · 数学 2016-10-26 Jingli Ren , Fangzhi Yu

In this paper, we study the existence and the property of the Hopf bifurcation in the two-strategy replicator dynamics with distributed delays. In evolutionary games, we assume that a strategy would take an uncertain time delay to have a…

系统与控制 · 计算机科学 2017-03-21 Nesrine Ben Khalifa , Rachid El Azouzi , Yezekael Hayel

In this paper, a mathematical model of pneumococcal pneumonia with time delays is proposed. The stability theory of delay differential equations is used to analyze the model. The results show that the disease-free equilibrium is…

种群与进化 · 定量生物学 2019-01-16 Fulgensia Kamugisha Mbabazi , Joseph Y. T. Mugisha , Mark Kimathi

The traditional Wilson-Cowan model of excitatory and inhibitory mean field interactions in neuronal populations considers a weak Gamma distribution of time delays when processing inputs, and is obtained via a time-coarse graining technique…

动力系统 · 数学 2021-07-06 Eva Kaslik , Emanuel-Attila Kokovics , Anca Radulescu

This paper is devoted to the study of the stability of limit cycles of a nonlinear delay differential equation with a distributed delay. The equation arises from a model of population dynamics describing the evolution of a pluripotent stem…

偏微分方程分析 · 数学 2009-04-17 Mostafa Adimy , Fabien Crauste , Andrei Halanay , Mihaela Neamtu , Dumitru Opris

We consider a delay differential equation that occurs in the study of chronic myelogenous leukemia. After shortly reminding some previous results concerning the stability of equilibrium solutions, we concentrate on the study of stability of…

动力系统 · 数学 2010-03-23 Anca-Veronica Ion , Raluca-Mihaela Georgescu

This paper presents an investigation of the dynamics of two coupled non-identical FitzHugh-Nagumo neurons with quadratic term and delayed synaptic connection. We consider coupling strength and time delay as bifurcation parameters, and try…

混沌动力学 · 物理学 2016-02-29 Niloofar Farajzadeh Tehrani , MohammadReza Razvan
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