相关论文: Statistical analysis on detecting recombination si…
Single-strand breaks (SSBs) are the major DNA damage in the genome arising spontaneously as the outcome of genotoxins and intermediates of DNA transactions. SSBs play a crucial role in various biological processes and show a non-random…
We examine cosmic microwave background constraints on variations in the recombination history of the universe. We use a very general extension to the standard model of recombination characterized by two parameters, a and b, which multiply…
The primordial CMB at small angular scales is sensitive to the ionization and expansion history of the universe around the time of recombination. This dependence has been exploited to constrain the helium abundance and the effective number…
DNA is a promising storage medium, but its stability and occurrence of Indel errors pose a significant challenge. The relative occurrence of Guanine(G) and Cytosine(C) in DNA is crucial for its longevity, and reverse complementary base…
Gamma-ray bursts (GRBs) are commonly attributed to the demise of massive stars or the merger of binary compact objects. However, their varied emission characteristics strongly imply the existence of multiple GRB classes based on progenitor…
The discovery of many Earth-like planets has renewed interest in whether life and technological civilizations exist elsewhere. The Search for Extraterrestrial Intelligence (SETI) seeks evidence for technological civilizations via…
The growth channel of massive galaxies involving mergers can be studied via close pairs as putative merger progenitors, where the stellar populations of the satellite galaxies will be eventually incorporated into the massive primaries. We…
Motivation: Recombination rates vary considerably at the fine scale within mammalian genomes, with the majority of recombination occurring within hotspots of ~2 kb in width. We present a method for inferring the location of recombination…
The RecA protein and RecBCD complex are key bacterial components for the maintenance and repair of DNA, RecBCD a helicase-nuclease that uses homologous recombination to resolve double-stranded DNA breaks and also facilitating decoration of…
Circular double stranded DNA has different topological states which are defined by their linking numbers. Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase. Using Monte Carlo…
Recently much work in studying Gamma-Ray Burst has been devoted to revealing the nature of outburst mechanism and studies of GRB afterglows. These issues have also been closely followed by the quest for identifying GRB progenitors. In this…
Recent discoveries of transiting giant exoplanets ($R_p\gtrsim8\mathrm{~R_\oplus}$) around M dwarfs (GEMS) present an opportunity to investigate their atmospheric compositions and explore how such massive planets form around low-mass stars…
A comprehensive overview of the recent physics-inspired genome analysis tool, GenomeBits, is presented. This is based on traditional signal processing methods such as Discrete Fourier Transform (DFT). GenomeBits can be used to extract…
The discovery and genome analysis of Acanthamoeba polyphaga Mimivirus, the largest known DNA virus, challenged much of the accepted dogma regarding viruses. Its particle size (>400 nm), genome length (1.2 million bp) and huge gene…
According to the experimental evidence damage induced by densely ionizing radiation in mammalian cells is distributed along the DNA molecule in the form of clusters. The most critical constituent of DNA damage are double-strand breaks…
The Kinetoplast DNA (kDNA) is a two-dimensional Olympic-ring-like network of mutually linked 2.5 kb-long DNA minicircles found in certain parasites called Trypanosomes. Understanding the self-assembly and replication of this structure are…
We discuss how rotation and binary interactions may be related to the diversity of type Ibc supernovae and long gamma-ray bursts. After presenting recent evolutionary models of massive single and binary stars including rotation, the…
Most proteins involved in processing DNA accomplish their activities as a monomer or as a component of a multimer containing a relatively small number of other elements. They generally act locally, binding to one or a few small regions of…
The cell cycle is an orderly sequence of events which ultimately lead to the division of a single cell into two daughter cells. In the case of DNA damage by radiation or chemicals, the damage checkpoints in the $G_{1}$ and $G_{2}$ phases of…
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at…