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Despite substantial efforts, deep learning has not yet delivered a transformative impact on elucidating regulatory biology, particularly in the realm of predicting gene expression profiles. Here, we argue that genuine "foundation models" of…

This paper deals with the mathematical modelling of large strain magneto-viscoelastic deformations. Energy dissipation is assumed to occur both due to the mechanical viscoelastic effects as well as the resistance offered by the material to…

经典物理 · 物理学 2015-02-10 Prashant Saxena , Mokarram Hossain , Paul Steinmann

Some applied researchers hesitate to use nonparametric methods, worrying that they will lose power in small samples or overfit the data when simpler models are sufficient. We argue that at least some of these concerns are unfounded when…

统计方法学 · 统计学 2026-03-16 Antonio R. Linero

The paper presents a new type of weakly nonlinear two-scale model of inflatable periodic poroelastic structures saturated by Newtonian fluids. The periodic microstructures incorporate fluid inclusions connected to the fluid channels by…

偏微分方程分析 · 数学 2025-08-28 Eduard Rohan , Vladimír Lukeš

This paper describes a modification of Ehlers' model for the inelastic behavior of granular media. The modified model can be applied for describing the inelastic behavior of porous media. The key feature is a subtle change of the yield…

软凝聚态物质 · 物理学 2023-07-21 Martin Abendroth , Alexander Malik , Bjoern Kiefer

Spatially confined rigid membranes reorganize their morphology in response to the imposed constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing the deformation energy while compressing a membrane resting…

This review article highlights state-of-the-art data-driven techniques to discover, encode, surrogate, or emulate constitutive laws that describe the path-independent and path-dependent response of solids. Our objective is to provide an…

A static variational model for shape formation in heteroepitaxial crystal growth is considered. The energy functional takes into account surface energy, elastic misfit-energy and nucleation energy of dislocations. A scaling law for the…

偏微分方程分析 · 数学 2024-03-21 Lukas Abel , Janusz Ginster , Barbara Zwicknagl

A geometrically nonlinear finite element model is developed for the bending analysis of micropolar Timoshenko beams using the principle of virtual displacements and linear Lagrange interpolation functions. The nonlinearity enters the model…

经典物理 · 物理学 2019-02-28 Praneeth Nampally , Anssi T. Karttunen , JN Reddy

A three-dimensional mesoscopic viscoplasticity model for simulating rate-dependent plasticity and creep in unidirectional thermoplastic composites is presented. The constitutive model is a transversely isotropic extension of an isotropic…

计算工程、金融与科学 · 计算机科学 2025-10-01 P. Hofman , D. Kovačević , F. P. van der Meer , L. J. Sluys

Understanding the biomechanics of the heart in health and disease plays an important role in the diagnosis and treatment of heart failure. The use of computational biomechanical models for therapy assessment is paving the way for…

We formulate a model for the dynamic growth of a membrane developing in a flow as the result of a precipitation reaction, a situation inspired by recent microfluidic experiments. The precipitating solid introduces additional forces on the…

流体动力学 · 物理学 2020-03-18 P. S. Eastham , M. N. J. Moore , N. G. Cogan , Q. Wang , O. Steinbock

Long length-scale structural deformations of DNA play a central role in many biological processes including gene expression. The elastic rod model, which uses a continuum approximation, has emerged as a viable tool to model deformations of…

计算物理 · 物理学 2010-02-08 Harish J. Palanthandalam-Madapusi , Sachin Goyal

The dynamics of a membrane is a coupled system comprising a moving elastic surface and an incompressible membrane fluid. We will consider a reduced elastic surface model, which involves the evolution equations of the moving surface, the…

偏微分方程分析 · 数学 2015-05-27 Wei Wang , Pingwen Zhang , Zhifei Zhang

Filamentous bio-materials such as fibrin or collagen networks exhibit an enormous stiffening of their elastic moduli upon large deformations. This pronounced nonlinear behavior stems from a significant separation between the stiffnesses…

软凝聚态物质 · 物理学 2019-05-21 Robbie Rens , Carlos Villarroel , Gustavo Düring , Edan Lerner

In complex materials, numerous intertwined phenomena underlie the overall response at macroscale. These phenomena can pertain to different engineering fields (mechanical , chemical, electrical), occur at different scales, can appear as…

材料科学 · 物理学 2016-06-15 Pierre Jehel

This monograph presents a geometric modeling method nonlinear dynamical systems from experimental data . basis method is a qualitative approach to the analysis of linear models and construction of the symmetry groups of attractors of…

计算工程、金融与科学 · 计算机科学 2014-03-03 Evgeny Nikulchev

We propose a data-driven constitutive framework for anisotropic damage mechanics based on the second-order damage tensor approach for both compressible and incompressible materials. The formulation is thermodynamically consistent and…

应用物理 · 物理学 2025-08-11 Amirhossein Amiri-Hezaveh , Adrian Buganza Tepole

Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. We consider that molecules bind to either surface of a bilayer membrane and move to the opposite leaflet by flip--flop. When binding does not modify…

软凝聚态物质 · 物理学 2025-01-14 Hiroshi Noguchi

A simple kinetic model of a two-component deformable and reactive bilayer is presented. The two differently shaped components are interconverted by a nonequilibrium reaction, and a phenomenological coupling between local composition and…

软凝聚态物质 · 物理学 2009-11-11 Ramon Reigada , Javier Buceta , Katja Lindenberg