医学物理
Multi-energy CT has long demonstrated its ability to enhance image quality with material decomposition. Yet, it has largely been limited to applications that already have high contrast. More recently, x-ray phase-contrast (XPC) imaging has…
X-ray phase-contrast imaging has the potential to improve image contrast with lower dose by probing an object's refractive properties as well as its absorptive properties. To reconstruct a phase-contrast image from a raw dataset, a phase…
Recent advances in medical diagnostics have highlighted the importance of wearable technologies for continuous and real-time physiological monitoring. In this study, we introduce a flexible, self-powered triboelectric nanogenerator…
Proton Computed Tomography (pCT) provides a promising solution to enhance the accuracy of Relative Stopping Power (RSP) required for proton therapy planning. This research introduces a novel high-granularity pCT architecture that…
Purpose: Thyroid scintigraphy plays a vital role in diagnosing a range of thyroid disorders. While deep learning classification models hold significant promise in this domain, their effectiveness is frequently compromised by limited and…
Changes in the nervous system due to neurological diseases take place at very small spatial scales, on the order of the micro and nanometers. Developing non-invasive imaging methods for obtaining this microscopic information as quantitative…
Dark-field radiography is a novel X-ray imaging modality that enables complementary diagnostic information by visualizing the microstructural properties of lung tissue. Implemented via a Talbot-Lau interferometer integrated into a…
Purpose: To investigate dipole antennas with electronically switchable transmit field patterns to improve flip angle homogeneity in ultra-high field MRI Methods: An array of eight coaxial dipoles with electronically switchable $B_{1}^{\!+}$…
Purpose: To develop a new sequence, MIMOSA, for highly-efficient T1, T2, T2*, proton density (PD), and source separation quantitative susceptibility mapping (QSM). Methods: MIMOSA was developed based on 3D-quantification using an…
Three-dimensional (3D) printed preoperative planning models serve a critical role in the success of many medical procedures. However, many of these models do not portray the patient's complete anatomy due to their monolithic and static…
Ring-array ultrasound computed tomography has recently achieved sufficient maturity for clinical applications like breast imaging. Image reconstruction is achieved with state of art iterative algorithms (full waveform inversion in the…
Doing quantitative computed tomography (CT) using Bremsstrahlung sources requires an estimate of the spectrum emitted by the X-ray source. One method of beam hardening correction (BHC), as described by Lifton[1], first uses transmission…
The framework of ultrasound computed tomography (USCT) has recently re-emerged as a powerful, safe and operator-independent way to image the breast. State of the art image reconstruction methods are performed with iterative techniques based…
Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…
Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning…
Pulsed field ablation (PFA) has emerged as a non-thermal alternative to traditional thermal ablation techniques for the treatment of atrial fibrillation (AF). This study presents a patient-specific 3D computational framework to model the…
Kidney allograft fibrosis is a marker of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates if spectral diffusion MRI can help detect early development and mild/moderate…
The role of Helical Flow (HF) in human coronary arteries remains uncertain, yet its understanding promises unprecedented insights into atherosclerotic processes. In this study, we investigated the effects of HF and key haemodynamic…
Purpose: To evaluate the cumulative radiobiological impact of daily Megavoltage Cone-Beam Computed Tomography (MV-CBCT) imaging dose based on Normal Tissue Complication Probability (NTCP) and Excess Absolute Risk (EAR) of secondary…
Positronium Imaging requires two classes of events: double-coincidences originated from pair of back-to-back annihilation photons and triple-coincidences comprised with two annihilation photons and one additional prompt photon. The standard…