医学物理
Anemia is a global health concern, prompting the need for rapid and accurate diagnostic tools, especially for vulnerable populations. Estimating the blood lysis level (LL) and oxygen saturation (SO2) are essential not only for anemia but…
During an academic visit to the National Oncology Institute (ION), the low-dose-rate brachytherapy procedure with Cs-137 was observed in a patient with stage IIB cervical cancer. The experience provided insight into both the clinical…
Purpose: The pathway to clinical medical physics involves 3 distinct stages of accredited positions, including (i) graduate education, (ii) residency training & (iii) employment. While CAMPEP accredits programs & people, the type of…
Radiotherapy using very high-energy electron (VHEE) beams generated by a laser-plasma accelerator has garnered significant interest due to its dose distribution capabilities and potential to address limitations of traditional photon-based…
X-ray scatter has been a serious concern in computed tomography (CT), leading to image artifacts and distortion of CT values. The linear Boltzmann transport equation (LBTE) is recognized as a fast and accurate approach for scatter…
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. However, the physical conditions triggering the FLASH sparing…
Deep learning models for medical image analysis often suffer from performance degradation when applied to data from different scanners or protocols, a phenomenon known as domain shift. This study investigates this challenge in the context…
Accurately quantifying the energy loss rate of proton beams in liquid water is crucial for the precise application and improvement of proton therapy, whereas the slowing down of proton in water ices also plays an important role in…
Objective: To develop an accurate myocardial T1 mapping technique at 5T using Look-Locker-based multiple inversion-recovery with the real-time spoiled gradient echo (GRE) acquisition. Approach: The proposed T1 mapping technique (mIR-rt)…
Background: This study aimed to predict lesion-specific outcomes after stereotactic radiotherapy (SRT) in patients with brain metastases from malignant melanoma (MBM), using clinical, dosimetric, and pretherapeutic MRI data. Methods: In…
The field of histology relies heavily on antiquated tissue processing and staining techniques that limit the efficiency of pathologic diagnoses of cancer and other diseases. Current staining and advanced labeling methods are often…
Differentiable rendering has been widely adopted in computer graphics as a powerful approach to inverse problems, enabling efficient gradient-based optimization by differentiating the image formation process with respect to millions of…
This study aimed to assess the diagnostic utility of a conventional FLASH technique at 3T MRI in the detection of ILD patients in combination with functional and morphological information by a rather simple but straightforward approach for…
Myocardial infarction causes myocardium thinning, fibrosis, and progressive heart failure. Engineered human myocardium (EHM) is tested clinically as a first-in-class product for sustainable remuscularization in patients with advanced heart…
Mathematical modelling and computer simulation are increasingly being used alongside experiments to help optimise and guide the design of drug delivery systems. Recent drug delivery research has (i) highlighted the advantages of drug…
Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…
Machine learning (ML), including deep learning (DL) and radiomics-based methods, is increasingly used for cancer outcome prediction with PET and SPECT imaging. However, the comparative performance of handcrafted radiomics features (HRF),…
Quantitative imaging (QI) is demonstrating strong promise across multiple clinical applications. For clinical translation of QI methods, objective evaluation on clinically relevant tasks is essential. To address this need, multiple…
A wide range of methods currently exist for testing the presence of malaria, each with its own advantages and disadvantages. New technologies are urgently needed to develop more effective diagnosis tools to fight and eradicate malaria.…
Photoacoustic imaging (PAI), by combining high optical contrast with ultrasonic resolution, offers a promising noninvasive approach for dynamic monitoring of cerebral vasculature. However, transcranial PAI still faces significant challenges…