医学物理
Cerebral autoregulation (CA) is a fundamental mechanism that modulates cerebrovascular resistance, primarily by regulating the diameter of small cerebral vessels to maintain stable cerebral blood flow (CBF) in response to fluctuations in…
Objective. Proton beams enable localized dose delivery. Accurate range estimation is essential, but planning still relies on X-ray CT, which introduces uncertainty in stopping power and range. Proton CT measures water equivalent thickness…
Targeted Radionuclide Therapy (TRT) is a modern strategy in radiation oncology that aims to administer a potent radiation dose specifically to cancer cells using cancer-targeting radiopharmaceuticals. Accurate radiation dose estimation…
Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy, yet voxel-wise DL uncertainty maps are rarely presented to clinicians. Purpose: This study assessed how DL-generated uncertainty maps impact…
Standard apodization methods suppress side lobes but increase FWHM, reducing lateral resolution. Grating lobes can interfere with the main lobe, introducing artifacts in ultrasound images. A simple mathematical apodization function is…
Using inverse planning tools to create radiotherapy treatment plans is an iterative process, where clinical trade-offs are explored by changing the relative importance of different objectives and rerunning the optimizer until a desirable…
Seed implant brachytherapy (SIBT) is an effective cancer treatment modality; however, clinical planning often relies on manual adjustment of objective function weights, leading to inefficiencies and suboptimal results. This study proposes…
The-Bodega is a Matlab-based toolbox for simulating ground-truth datasets for Ultrasound Localization Microscopy (ULM)-a super resolution imaging technique that resolves microvessels by systematically tracking microbubbles flowing through…
A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked…
Objectives: MR elastography (MRE) offers valuable mechanical tissue characterization, however, in deep abdominal organs like the pancreas conventional single-driver, single-frequency approaches often fail. This study evaluates whether…
This study compares the propulsion of helical microrobots based on hard- and soft-magnetic elements under rotating magnetic fields. Results show that hard-magnetic microrobots achieved step-out frequencies and maximum propulsion speeds 4.5…
Microvascular imaging has advanced significantly with ultrafast data acquisition and improved clutter filtering, enhancing the sensitivity of power Doppler imaging to small vessels. However, the image quality remains limited by spatial…
\textbf{Objective: }To develop a real-time method for designing gradient waveforms for arbitrary $k$-space trajectories that are time-optimal and hardware-compliant. \textbf{Methods: }The gradient waveform is solved recursively under both…
In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging…
Precise knowledge of magnetic fields is crucial in many medical imaging applications like magnetic resonance imaging or magnetic particle imaging (MPI) as they are the foundation of these imaging systems. For the investigation of the…
Purpose: To develop and validate a practical framework to overcome common issues in inline deployment of established offline MR reconstruction, including (1) delay from lengthy reconstructions, (2) limited support for multi-scan input…
Ultra-high field 7T fMRI offers notable advantages over 3T fMRI, including higher signal-to-noise and contrast-to-noise ratios, enabling finer spatial and temporal resolution. This study explores the differences in activation maps from…
Galactic cosmic rays (GCR) are a principal source of ionizing radiation exposure for astronauts during deep space missions. Given the ambition to expand manned space exploration to distant destinations like Mars, it is essential to…
Wearable electronics are emerging as essential tools for health monitoring, haptic feedback, and human-computer interactions. While stable contact at the device-body interface is critical for these applications, it remains challenging due…
Background: Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, where small changes in beam configuration can significantly impact treatment quality, especially for proton RT. Mathematically,…