医学物理
Cone-beam computed tomography (CBCT) is widely used for image-guided radiotherapy (IGRT). It provides real time visualization at low cost and dose. However, photon scattering and beam hindrance cause artifacts in CBCT. These include…
Mandible Osteoradionecrosis (ORN) is one of the most severe adverse events (AEs) for head and neck (H&N) cancer radiotherapy. Previous retrospective investigations on real-world data relied on conventional statistical models that primarily…
Background: Accurate and fast dose calculation is essential for optimizing carbon ion therapy. Existing machine learning (ML) models have been developed for other radiotherapy modalities. They use patient data with uniform CT imaging…
Aortic valve replacement is a key surgical procedure for treating aortic valve pathologies, such as stenosis and regurgitation. The precise placement of the prosthetic valve relative to the native aortic annulus plays a critical role in the…
Background and Purpose: Voxel-based analysis (VBA) helps to identify dose-sensitive regions by aligning individual dose distributions within a common coordinate system (CCS). Accurate deformable image registration (DIR) is essential for…
This roadmap provides a comprehensive and forward-looking perspective on the individualized application and safety of non-ionizing radiation (NIR) dosimetry in diagnostic and therapeutic medicine. Covering a wide range of frequencies, i.e.,…
Computational ultrasound imaging (cUSi) with few elements and spatial field encoding can provide high-resolution volumetric B-mode imaging. In this work, we extend its application to 4D carotid artery (CA) flow imaging using a custom…
Purpose: We developed an artificial neural network (ANN) combining radiomics with clinical and dosimetric features to predict the extent of body mass index (BMI) increase after surgery and proton therapy, with advantage of improved accuracy…
Purpose: Convolutional neural networks (CNNs) are promising in predicting treatment outcome for pediatric craniopharyngioma while the decision mechanisms are difficult to interpret. We compared the activation maps of CNN with hand crafted…
Objective: Research on eye lens dosimetry for radiation workers has increased after the 2012 ICRP118 update on eye lens dose limits. However, corneal dosimetry remains underexplored due to historical focus and measurement challenges. This…
Cell tracking is a subject of active research gathering great interest in medicine and biology. Positron emission tomography (PET) is well suited for tracking radio-labeled cells in vivo due to its exceptional sensitivity and whole-body…
This study presents FREDopt, a newly developed GPU-accelerated open-source optimization software for simultaneous proton dose and dose-averaged LET (LETd) optimization in IMPT treatment planning. FREDopt was implemented entirely in Python,…
Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the benefits of both optical and acoustic imaging modalities, which provides functional and molecular optical contrasts of deep tissue. Commonly used ultrasound…
Background: Mechanical ventilation is life-saving for preterm infants with respiratory distress syndrome but can also contribute to lung injury and long-term morbidity. Protective ventilation strategies are recommended, yet implementation…
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…
Introduction: This study uses KV CBCT based Synthetic CT (sCT) generated through Velocity workstation and compare the target and normal tissue doses with Adaptive plan CT doses. Methods: Thirty head and neck cancer patients undergoing…
Obstacle crossing is an essential component of human locomotion, particularly for individuals with lower limb amputations who face elevated risks of imbalance and falls. While prior studies have explored this task, they often lack a…
This article reviews the evolving field of radiobiology, emphasizing the need for advanced multiscale, mechanistic models to optimize radiopharmaceutical therapies (RPT). While the traditional linear-quadratic (LQ) model underpins external…
Objective: Cone-beam computed tomography (CBCT) provides a low-dose imaging alternative to conventional CT, but suffers from noise, scatter, and artifacts that degrade image quality. Synthetic CT (sCT) aims to translate CBCT to high-quality…
Purpose: Pencil beam scanning proton therapy is sensitive to respiratory motion, leading to potential dose inhomogeneities due to interplay effects. We developed and validated a predictive framework to assess interplay and motion robustness…