医学物理
Objective The concentration of bilirubin in blood or serum is useful for assessing liver function as well as monitoring treatment. This study evaluates the clinical performance of a novel point-of-care (PoC) device for the detection of…
Glioblastoma (GBM) is an aggressive brain tumor in which IDH mutation status is a key prognostic biomarker, but traditional testing requires invasive biopsies, emphasizing the need for non-invasive approaches. In this multi-center study, we…
Propagation-based phase-contrast X-ray imaging is a promising technique for in~vivo medical imaging, offering lower radiation doses than traditional attenuation-based imaging. Previous studies have focused on X-ray energies below 50 keV for…
Background: We aimed to quantify hepatic vessel volumes across chronic liver disease stages and healthy controls using deep learning-based magnetic resonance imaging (MRI) analysis, and assess correlations with biomarkers for liver…
Quantitative MRI (qMRI) estimates tissue properties of interest from measured MRI signals. This process is conventionally achieved by model fitting, whose computational expense limits qMRI's clinical use, motivating recent development of…
Proton therapy provides superior dose conformity compared with photon radiotherapy, concentrating radiation within the tumor while sparing adjacent healthy tissue. This advantage has been most effectively realized for static tumors in…
Objective. The technology employed in magnetic resonance imaging (MRI) systems has evolved continuously, resulting in MRI scanners with stronger static magnetic fields (SMF) B0, faster and stronger gradient magnetic fields, and more…
Proton therapy can achieve a highly targeted treatment by utilising the advantageous dosimetric characteristics of the Bragg Peak. Protons traversing through a material will deposit their maximum energy at the Bragg Peak through ionisation…
We propose a signal acquisition and modeling framework for multi-component tissue quantification that encompasses transmit field inhomogeneity, multi-component relaxation and magnetization transfer (MT) effects. By applying off-resonance…
Flow diversion has become a key treatment modality for selected intracranial aneurysms, relying on the principle that a dense mesh of stent wires disrupts blood flow into the aneurysm sac, promoting thrombosis and vessel reconstruction.…
Background: A growing number of cancer patients with brain metastases can benefit from stereotactic radiosurgery (SRS) thanks to recent advances in systemic therapies. With an increasing patient load, single-isocenter treatments on widely…
The effects of the aortic geometry on its mechanics and blood flow, and subsequently on aortic pathologies, remain largely unexplored. The main obstacle lies in obtaining patient-specific aorta models, an extremely difficult procedure in…
A comprehensive numerical solution is developed for the transient thermo-elasto-hydrodynamic (TEHD) characteristics of mechanical face seals. Transient lubrication features of the fluid film, transient thermal deformation features of the…
The purpose of this study is to propose a brain tissue-selective, optimized slice-by-slice B0 field shimming for high-resolution brain diffusion MRI. We incorporated actual gradient fields of X, Y, and Z gradient coils in the calculation of…
Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due…
Blood transfusion remains a cornerstone of modern medicine, saving countless lives daily. Yet the quality of transfused blood varies dramatically among donors-a critical factor often overlooked in clinical practice. Rapid, benchtop, and…
Sickle cell disease (SCD) remains a critical global health issue, with high child mortality in low-resource regions. Early screening and diagnosis is essential for improving health outcomes, but conventional screening methods are unsuitable…
Motion remains a key challenge in MRI, as both involuntary (e.g., head motion) and voluntary (e.g., joint motion) movement can degrade image quality or provide opportunities for dynamic assessment. Existing motion sensing methods, such as…
Transcranial ultrasound imaging is usually limited by skull-induced attenuation and high-order aberrations. By using contrast agents such as microbubbles in combination with ultrafast imaging, not only can the signal-to-noise ratio be…
Quantitative magnetization transfer (MT) imaging enables non-invasive characterization of the macromolecular environment of tissues. However, recent work has highlighted that the quantification of MT parameters exhibits orientation…