医学物理
Muscle force sharing is typically resolved by minimizing a specific objective function to approximate neural control strategies. An inverse optimal control approach was applied to identify the "best" objective function, among a positive…
We investigated the effects of scanning speed, beam configuration, and dose-rate modeling on the FLASH effect in post-mastectomy proton transmission-beam (TB) planning and evaluated whether optimizing the spot-scanning path can enhance…
Purpose: To develop and evaluate a real-time method for automatic planning and measurement of fetal femur length - an important indicator of antenatal growth - during MRI. While routinely assessed by ultrasound, MRI-based femur length…
Functional Spectral Imaging (FSI) models image formation as the recovery of tissue surrogates such as density and stiffness from spectral perturbations of a self-adjoint elliptic operator. Rather than relying on reflectivity or relaxation…
Fear of flying is a serious problem that affects millions of individuals. Exposure therapy for fear of flying is an effective therapy technique. However, exposure therapy is also expensive, logistically difficult to arrange, and presents…
Purpose: To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods: The Cram\'er-Rao bound (CRB) for variance assessment was employed on Bloch-McConnell-based simulated signals, followed…
Divergent wave imaging with coherent compounding allows obtaining broad field of view and higher frame rate with respect to line by line insonification. However, the spatial and contrast resolution crucially depends on the weights applied…
Ultrasound Localization Microscopy (ULM) has proven effective in resolving microvascular structures and local mean velocities at sub-diffraction-limited scales, offering high-resolution imaging capabilities. Dynamic ULM (DULM) enables the…
Airway mucus is a complex gel with an anisotropic three-dimensional network structure. As a crucial component of the respiratory defense barrier, it plays a vital role in maintaining airway hydration and supporting the function of airway…
This work investigates the change in cell survival predicted by the local effect model (LEM) for an irradiated cell containing metal nanoparticles (MNPs) depending on the distribution of neighboring cells and the uptake of MNPs into the…
Diffuse correlation spectroscopy (DCS) analyzes the autocorrelation function of photons scattered by red blood cells, enabling non-invasive, continuous measurement of deep tissue blood flow at the bedside. Multi-layer DCS models (two- and…
Intraoperative visualization of hemodynamics is crucial for accurate diagnosis and informed surgical decision-making. In neurosurgery, indocyanine green fluorescence imaging (ICG-FI) is the gold standard for assessing blood flow and…
At the Heidelberg Ion-Beam Therapy Center, the track structure of carbon ions of therapeutic energy after penetrating layers of simulated tissue was investigated for the first time. Measurements were conducted with carbon ion beams of…
Density Compensation Function (DCF) is widely used in non-Cartesian MRI reconstruction, either for direct Non-Uniform Fast Fourier Transform (NUFFT) reconstruction or for iterative undersampled reconstruction. Current state-of-the-art…
Articular cartilage is a musculoskeletal soft tissue renowned for its unique mechanical properties. Understanding both its hierarchical structure and the interplay between its constituents could shed light on the mechanical competence of…
X-ray photon-counting computed tomography (PCCT) for extremity allows multi-energy high-resolution (HR) imaging but its radiation dose can be further improved. Despite the great potential of deep learning techniques, their application in HR…
In positron emission tomography (PET), it is indispensable to perform attenuation correction in order to obtain the quantitatively accurate activity map (tracer distribution) in the body. Generally, this is carried out based on the…
Diffusion models have recently enabled state-of-the-art reconstruction of positron emission tomography (PET) images while requiring only image training data. However, domain shift remains a key concern for clinical adoption: priors trained…
At the Maastro Proton Therapy Center in Maastricht, patient-specific quality assurance (PSQA) using an independent GPU-accelerated Monte Carlo (MC) calculation has fully replaced conventional measurements, which are time-consuming and have…
Current radiation therapy treatment planning is limited by suboptimal plan quality, inefficiency, and high costs. This perspective paper explores the complexity of treatment planning and introduces Human-Centric Intelligent Treatment…