医学物理
Malignant membranes cluster nutrient transporters within glycan-rich domains, sustaining metabolism through redundant intake routes. A theoretical framework links interfacial chemistry to transport suppression and energetic or redox…
Cardiac substructure delineation is emerging in treatment planning to minimize the risk of radiation-induced heart disease. Deep learning offers efficient methods to reduce contouring burden but currently lacks generalizability across…
Purpose: To evaluate a Deep-Learning-enhanced MUlti-PArametric MR sequence (DL-MUPA) for treatment response assessment for brain metastases patients undergoing stereotactic radiosurgery (SRS) and head-and-neck (HnN) cancer patients…
Low-dose computed tomography (LDCT) is the current standard for lung cancer screening, yet its adoption and accessibility remain limited. Many regions lack LDCT infrastructure, and even among those screened, early-stage cancer detection…
Achieving an optimal biomechanical environment within bone scaffolds is critical for promoting tissue regeneration, particularly in load-bearing anatomical sites where rigid fixation can induce stress shielding and compromise healing.…
Radiation chemistry of model systems irradiated with ultra-high dose-rates (UHDR) is key to obtain a mechanistic understanding of the sparing of healthy tissue, which is called the FLASH effect. It is envisioned to be used for efficient…
Constrained Spherical Deconvolution (CSD) is widely used to estimate the white matter fiber orientation distribution (FOD) from diffusion MRI data. Its angular resolution depends on the maximum spherical harmonic order ($l_{max}$): low…
More than a century ago, Karl Bernhard Zoeppritz derived the equations that determine the reflected and transmitted coefficients at a planar interface for an incident seismic wave. The coefficients so obtained are a function of the elastic…
Background and Purpose: Increasing the number of arcs in volumetric modulated arc therapy (VMAT) allows for better intensity modulation and may improve plan quality. However, this leads to longer delivery times, which may cause patient…
When acquiring PET images, body motions are unavoidable, given that the acquisition time could last 10-20 minutes or more. These motions can seriously deteriorate the quality of the final image at the level of image reconstruction and…
Background and Purpose: Reirradiation for non-small cell lung cancer (NSCLC) is commonly delivered using coplanar techniques. In this study, we developed a beam orientation optimization algorithm for reirradiation planning to investigate…
Purpose: To develop a virtual reality simulator for high dose rate prostate brachytherapy and to test whether participation is associated with immediate gains in self-reported confidence across predefined procedural domains in two cohorts.…
Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…
Degradation of joint cartilages can result in osteoarthritis (OA) affecting about 10\% of the US population and responsible for significant hospitalization costs. While observations show that low dose radiation treatments (LDRT) bring…
The cluster dose concept offers an alternative to the radiobiological effectiveness (RBE)-based model for describing radiation-induced biological effects. This study examines the application of a neural network to predict cluster dose…
Purpose: We presented a GPU-based MC framework, ARCHER-EPID, specifically designed for EPID transit dosimetry, with improving accuracy and efficiency. Methods: A comprehensive MC framework was developed to perform full radiation transport…
Osteoporosis and osteopenia remain vastly underdiagnosed. Current clinical screening relies almost exclusively on dual-energy X-ray absorptiometry (DXA), which measures bone mineral density (BMD) but fails to capture the compositional…
Low-dose computed tomography (LDCT) reduces patient radiation exposure but introduces substantial noise that degrades image quality and hinders diagnostic accuracy. Existing denoising approaches often require many diffusion steps, limiting…
Pulse Transit Time (PTT) is a measure of arterial stiffness and a physiological marker associated with cardiovascular function, with an inverse relationship to diastolic blood pressure (DBP). We present the first AI-enabled mmWave system…
Physiologically based pharmacokinetic (PBPK) models provide a mechanistic framework for simulating radiopharmaceutical kinetics and estimating patient-specific absorbed doses (ADs). PBPK models incorporate prior knowledge of patient…