医学物理
Objective: Spatiotemporal optimization in radiation therapy involves determining the optimal number of dose delivery fractions (temporal) and the optimal dose per fraction (spatial). Traditional approaches focus on maximizing the…
Purpose: LATTICE, a form of spatially fractionated radiation therapy that delivers high-dose peaks and low-dose valleys within the target, has been clinically utilized for treating bulky tumors. However, its application to…
Euler angle representation in biomechanical analysis allows straightforward description of joints rotations. However, application of Euler angles could be limited due to singularity called gimbal lock. Quaternions offer an alternative way…
Photoacoustic imaging combines the high contrast of optical imaging with the deep penetration depth of ultrasonic imaging, showing great potential in cerebrovascular disease detection. However, the ultrasonic wave suffers strong attenuation…
This work presents a biventricular electromechanical human heart model that is comprehensive and clinically relevant, integrating a realistic 3D heart geometry with both systemic and pulmonary hemodynamics. The model uses a two-way…
Traditional sources of quantum-entangled photons, such as spontaneous parametric down-conversion, suffer from low flux, limiting clinical applications. We investigated whether clinical megavoltage (MV) radiotherapy beams can serve as…
MTV is increasingly recognized as an accurate estimate of disease burden, which has prognostic value, but its implementation has been hindered by the time-consuming need for manual segmentation of images. Automated quantitation using…
LAFOV PET/CT has the potential to unlock new applications such as ultra-low dose PET/CT imaging, multiplexed imaging, for biomarker development and for faster AI-driven reconstruction, but further work is required before these can be…
The science and clinical practice of medical physics has been integral to the advancement of radiology and radiation therapy for over a century. In parallel, advances in surgery - including intraoperative imaging, registration, and other…
Ultra-high dose rate irradiations to water indicate an enhancement of radical-radical reactions, which could potentially correlate with the Flash effect. The purpose of this work was to extend gMicroMC to support multiple pulse simulations…
This paper describes the production and tests performed with the tungsten collimator prototype produced using laser powder bed fusion technology in a converging geometry. This prototype has been tested for being the anti-scatter grid for…
Magnetoencephalography using optically pumped magnetometers (OPM-MEG) is gaining significant traction as a neuroimaging tool, with the potential for improved performance and practicality compared to conventional instrumentation. However,…
Accurate breast MRI lesion detection is critical for early cancer diagnosis, especially in high-risk populations. We present a classification pipeline that adapts a pretrained foundation model, the Medical Slice Transformer (MST), for…
This study explores the application of Quantum Convolutional Neural Networks (QCNNs) for brain tumor classification using MRI images, leveraging quantum computing for enhanced computational efficiency. A dataset of 3,264 MRI images,…
Three-dimensional (3D) printing of bioelectronics offers a versatile platform for fabricating personalized and structurally integrated electronic systems within biological scaffolds. Biodegradable electronics, which naturally dissolve after…
This work explores the behaviour of demagnetizing tensors for general ellipsoids under arbitrary rotations in homogeneous magnetic fields. The work is motivated by the concerns in magnetic resonance imaging safety and their practical…
MRI systems are traditionally engineered to produce close to idealized performance, enabling a simplified pulse sequence design philosophy. An example of this is control of eddy currents produced by gradient fields; usually these are…
Aortic valve stenosis (AVS) presents challenges in asymptomatic detection, resulting in delayed intervention. This study aims to understand how AVS affects pulse wave (PW) morphology. A PW database of 16,038 virtual subjects aged 50 to 75…
Anemia is a global health concern, prompting the need for rapid and accurate diagnostic tools, especially for vulnerable populations. Estimating the blood lysis level (LL) and oxygen saturation (SO2) are essential not only for anemia but…
During an academic visit to the National Oncology Institute (ION), the low-dose-rate brachytherapy procedure with Cs-137 was observed in a patient with stage IIB cervical cancer. The experience provided insight into both the clinical…