医学物理
Purpose: To implement a framework generating synthetic spectral panoramic images from single energy CT volumes. Using the framework output to compare the synthetic images against experimental spectral panoramic images for…
Purpose: The DANTE-SPACE sequence facilitates three-dimensional intracranial vessel wall imaging with simultaneous suppression of blood and cerebrospinal fluid (CSF). However, the achieved image contrast depends closely on the selected…
We demonstrate that a simple, unscanned polarization-sensitive optical coherence tomography needle probe can be used to perform layer identification in biological tissues. Broadband light from a laser centered at 1310 nm was sent through a…
The production of 47Sc, a promising radioisotope for targeted radionuclide therapy, by means of hospital-cyclotron reactions is investigated. Two possible routes are considered: the proton-induced reaction on enriched 50Ti targets and the…
This article presents the algorithms developed by the Core Imaging Library (CIL) developer team for the Helsinki Tomography Challenge 2022. The challenge focused on reconstructing 2D phantom shapes from limited-angle computed tomography…
Purpose: This study explored the feasibility of a streamlined pin-shaped ridge filter (pin-RF) design for single-energy proton FLASH planning. Methods: An inverse planning framework integrated within a TPS was established for FLASH…
Vitrification is a promising approach for ice-free cryopreservation of biological material, but progress is hindered by the limited set of experimental tools for studying processes in the interior of the vitrified matter. Isochoric…
Currently, a large number of stored tissue samples are unavailable for spectroscopic study without the time consuming and destructive process of paraffin removal. Instead, a structurally sensitive technique, sum frequency generation, and a…
Purpose: Field-to-susceptibility inversion in quantitative susceptibility mapping (QSM) is ill-posed and needs numerical stabilization through either regularization or oversampling by acquiring data at three or more object orientations.…
Ongoing effort has been devoted to applying metamaterials to boost the imaging performance of magnetic resonance imaging owing to their unique capacity for electromagnetic field confinement and enhancement. However, there are still major…
In this article, we propose a new BSS approach for identifying skin diseases from RGB images that proceeds in two steps. We begin by separating the three main chromophores (oxyhemoglobin, deoxyhemoglobin and melanin) using Non-negative…
We have used the TOPAS Geant4-based package to create a parametric simulation of a new TOF-PET scanner design based on a low atomic number scintillator. TOPAS was extended to provide complete information on individual particle position,…
The sterilization of medical devices using the gamma rays from the decay of cobalt-60 has accumulated decades of experience of the performance of the materials and devices that are irradiated. The use of radiation using electron beams and…
There is evidence of synergy between radiotherapy and immunotherapy. Radiotherapy can increase liberation of tumor antigens, causing activation of antitumor T-cells. This effect can be boosted with immunotherapy. Radioimmunotherapy has…
We conducted a multi-institutional audit of dosimetric variability between FLASH and conventional dose rate (CONV) electron irradiations by using an anatomically realistic 3D-printed mouse phantom. A CT scan of a live mouse was used to…
Background and Objectives: The mechanics of the nucleus depends on cellular structures and architecture, and impact a number of diseases. Nuclear mechanics is yet rather complex due to heterogeneous distribution of dense heterochromatin and…
Objectives: We propose a deep learning (DL) multi-task learning framework using convolutional neural network (CNN) for a direct conversion of single-energy CT (SECT) to three different parametric maps of dual-energy CT (DECT):…
Although rodent models are a predominant study model in neuroscience research, research investigating healthy rodent brain maturation remains limited. This motivates further study of normal brain maturation in rodents to exclude confounds…
Integrating optical diffraction tomography with imaging flow cytometry enables label-free quantifications of the three-dimensional (3D) morphology and hemoglobin content of red blood cells (RBCs) in their natural form. Self-rotation of RBCs…
Ultrasound is a key technology in healthcare, and it is being explored for non-invasive, wearable, continuous monitoring of vital signs. However, its widespread adoption in this scenario is still hindered by the size, complexity, and power…