相关论文: Modeling oscillatory Microtubule--Polymerization

We study the emergence of periodic oscillations through a Hopf bifurcation in a scalar diffusion equation on the half line coupled to a dynamic boundary condition. Our results quantify the effect of delay through the buffering in the…

Microtubules are stiff filamentary proteins that constitute an important component of the cytoskeleton of cells. These are known to exhibit a dynamic instability. A steadily growing microtubule can suddenly start depolymerizing very…

Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in…

Hydrodynamic instabilities often cause spatio-temporal pattern formations and transitions between them. We investigate a model experimental system, a density oscillator, where the bifurcation from a resting state to an oscillatory state is…

A simple stochastic model which describes microtubule dynamics and explicitly takes into account the relevant biochemical processes is presented. The model incorporates binding and unbinding of monomers and random phosphate release inside…

We prove that the famous diffusive Brusselator model can support more complicated spatial-temporal wave structure than the usual temporal-oscillation from a standard Hopf bifurcation. In our investigation, we discover that the diffusion…

This work investigates the emergence of oscillations in one of the simplest cellular signaling networks exhibiting oscillations, namely, the dual-site phosphorylation and dephosphorylation network (futile cycle), in which the mechanism for…

This paper provides the phase transition analysis of a reaction diffusion equations system modeling dynamic instability of microtubules. For this purpose we have generalized the macroscopic model studied by Mour\~ao et all [MSS]. This model…

In this work we prove occurrence of a super-critical Hopf bifurcation in a model of white blood cell formation structured by three maturation stages. We provide an explicit analytical expression for the bifurcation point depending on model…

A density oscillator exhibits limit-cycle oscillations driven by the density difference of the two fluids. We performed two-dimensional hydrodynamic simulations with a simple model, and reproduced the oscillatory flow observed in…

We report an experimental study of the dynamics of an air-fluidized thin granular layer. Near-onset behavior of this shallow fluidized bed was described in the earlier paper (Tsimring et al, 1999). Above the threshold of fluidization the…

Cluster synchronization is a fundamental phenomenon in systems of coupled oscillators. Here, we investigate clustering patterns that emerge in a unidirectional ring of four delay-coupled electrochemical oscillators. A voltage parameter in…

We discuss a bifurcation scenario which creates periodic pulsating solutions in slow-fast delayed systems through a cascade of almost simultaneous Hopf bifurcations. This scenario has been previously associated with formation of pulses in a…

We analyze a thermodynamically consistent model of CMOS-based ring oscillators near the onset of coherent voltage oscillations. For driving voltages close to the critical value, we derive the normal form of the Hopf bifurcation that…

The effect of a temporal modulation at three times the critical frequency on a Hopf bifurcation is studied in the framework of amplitude equations. We consider a complex Ginzburg-Landau equation with an extra quadratic term, resulting from…

Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge once the colony…

This paper presents a general framework to derive the weakly nonlinear stability near a Hopf bifurcation in a special class of multi-scale reaction-diffusion equations. The main focus is on how the linearity and nonlinearity of the fast…

Starting from the hypothesis that the tubulin dimer is a conformationally bistable molecule - fluctuating between a curved and a straight configuration at room temperature - we develop a model for polymorphic dynamics of the microtubule…

We investigate the oscillatory dynamics and bifurcation structure of a reaction-diffusion system with bistable nonlinearity and mass conservation, which was proposed by [Otsuji et al, PLoS Comp. Biol. 3 (2007), e108]. The system is a useful…

Certain regulatory proteins influence the polymerization dynamics of microtubules by inducing catastrophe with a rate that depends on the microtubule length. Using a discrete formulation, here we show that, for a catastrophe rate…