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The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and…

统计方法学 · 统计学 2012-08-17 Alessandro Baldi Antognini , Maroussa Zagoraiou

The purpose of a phase I dose-finding clinical trial is to investigate the toxicity profiles of various doses for a new drug and identify the maximum tolerated dose. Over the past three decades, various dose-finding designs have been…

统计方法学 · 统计学 2021-11-25 Yunshan Duan , Shijie Yuan , Yuan Ji , Peter Mueller

Given n experiment subjects with potentially heterogeneous covariates and two possible treatments, namely active treatment and control, this paper addresses the fundamental question of determining the optimal accuracy in estimating the…

机器学习 · 统计学 2024-11-13 Jiachun Li , David Simchi-Levi , Yunxiao Zhao

A/B test, a simple type of controlled experiment, refers to the statistical procedure of experimenting to compare two treatments applied to test subjects. For example, many IT companies frequently conduct A/B tests on their users who are…

统计方法学 · 统计学 2026-05-12 Qiong Zhang , Lulu Kang

Robotic performance emerges from the coupling of body and controller, yet it remains unclear when morphology-control co-design is necessary. We present a unified framework that embeds morphology and control parameters within a single neural…

神经与进化计算 · 计算机科学 2025-10-10 Yi Zhang , Yue Xie , Tao Sun , Fumiya Iida

Educational research often studies subjects that are in naturally clustered groups of classrooms or schools. When designing a randomized experiment to evaluate an intervention directed at teachers, but with effects on teachers and their…

应用统计 · 统计学 2009-08-17 Brenda Jenney , Sharon Lohr

As quantum technology advances, the efficient design of quantum circuits has become an important area of research. This paper provides an introduction to the MCT quantum circuit design problem for reversible Boolean functions with the…

最优化与控制 · 数学 2025-07-10 Jihye Jung , Kevin Dalmeijer , Pascal Van Hentenryck

A new method is developed to deal with the problem that a complex decentralized control system needs to keep centralized control performance. The systematic procedure emphasizes quickly finding the decentralized subcontrollers that matching…

系统与控制 · 计算机科学 2018-09-05 Ying Huang , Jiyang Dai , Chen Peng

Transition Matching (TM) is an emerging paradigm for generative modeling that generalizes diffusion and flow-matching models as well as continuous-state autoregressive models. TM, similar to previous paradigms, gradually transforms noise…

机器学习 · 计算机科学 2025-12-16 Uriel Singer , Yaron Lipman

The selection of an appropriate control strategy is essential for ensuring safe operation in autonomous driving. While numerous control strategies have been developed for specific driving scenarios, a comprehensive comparative assessment of…

系统与控制 · 电气工程与系统科学 2023-11-15 Antonio Artuñedo , Marcos Moreno-Gonzalez , Jorge Villagra

Modeling real processes often results in several suitable models. In order to be able to distinguish, or discriminate, which model best represents a phenomenon, one is interested, e.g., in so-called T-optimal designs. These consist of the…

最优化与控制 · 数学 2022-08-30 David Mogalle , Philipp Seufert , Jan Schwientek , Michael Bortz , Karl-Heinz Küfer

A mathematical model for time development of metastases and their distribution in size and carrying capacity is presented. The model is used to theoretically investigate anti-cancer therapies such as surgery and chemical treatments…

组织与器官 · 定量生物学 2013-06-21 Sebastien Benzekry , Dominique Barbolosi , Assia Benabdallah , Florence Hubert , Philip Hahnfeldt

This paper provides a systematic review of emerging control techniques used for railway Virtual Coupling (VC) studies. Train motion models are first reviewed, including model formulations and the force elements involved. Control objectives…

数值分析 · 数学 2023-03-22 Qing Wu , Xiaohua Ge , Qing-Long Han , Yafei Liu

This paper studies circular designs for interference models, where a treatment assigned to a plot also affects its neighboring plots within a block. For the purpose of estimating total effects, the circular neighbor balanced design was…

统计方法学 · 统计学 2022-06-02 Xiangshun Kong , Xueru Zhang , Wei Zheng

We propose a model for the intersection of two urban streets. The traffic status of the crossroads is controlled by a set of traffic lights which periodically switch to red and green with a total period of T. Two different types of…

统计力学 · 物理学 2007-05-23 M. Ebrahim Fouladvand , Masoud Nematollahi , Farzad Zolfaghari

Many highly reliable products are designed to function for years without failure. For such systems accelerated degradation testing may provide significance information about the reliability properties of the system. In this paper, we…

应用统计 · 统计学 2021-10-13 Helmi Shat , Rainer Schwabe

We consider the optimal experimental design problem of allocating subjects to treatment or control when subjects participate in multiple, separate controlled experiments within a short time-frame and subject covariate information is…

统计方法学 · 统计学 2024-12-16 William Fisher , Qiong Zhang , Lulu Kang , Xinwei Deng

Hybrid quantum-classical algorithms hold great promise for solving quantum control problems on near-term quantum computers. In this work, we employ the hybrid framework that integrates digital quantum simulation with classical optimization…

量子物理 · 物理学 2025-07-01 Tangyou Huang , Jing-Jun Zhu , Zhong-Yi Ni

Performing optimal Bayesian design for discriminating between competing models is computationally intensive as it involves estimating posterior model probabilities for thousands of simulated datasets. This issue is compounded further when…

统计方法学 · 统计学 2022-04-07 Markus Hainy , David J. Price , Olivier Restif , Christopher Drovandi

We consider the problem of designing experiments for investigating particle in-flight properties in thermal spraying. Observations are available on an extensive design for an initial day and thereafter in limited number for any particular…

应用统计 · 统计学 2013-12-17 Holger Dette , Laura Hoyden , Sonja Kuhnt , Kirsten Schorning