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We numerically study a disordered model for the RNA secondary structure and we find that it undergoes a phase transition, with a breaking of the replica symmetry in the low temperature region (like in spin glasses). Our results are based on…

无序系统与神经网络 · 物理学 2009-10-31 A. Pagnani , G. Parisi , F. Ricci-Tersenghi

We analyze different microscopic RNA models at zero temperature. We discuss both the most simple model, that suffers a large degeneracy of the ground state, and models in which the degeneracy has been remove, in a more or less severe…

无序系统与神经网络 · 物理学 2009-11-07 Enzo Marinari , Andrea Pagnani , Federico Ricci-Tersenghi

Models for RNA secondary structures (the topology of folded RNA) without pseudo knots are disordered systems with a complex state-space below a critical temperature. Hence, a complex dynamical (glassy) behavior can be expected, when…

无序系统与神经网络 · 物理学 2008-02-02 S. Wolfsheimer , B. Burghardt , A. Mann , A. K. Hartmann

We study the folding of RNA secondary structures with quenched sequence randomness by means of the constrained annealing method. A thermodynamic phase transition is induced by including the conformational weight of loop structures. In…

生物物理 · 物理学 2020-02-05 Flavio Iannelli , Yevgeni Mamasakhlisov , Roland R. Netz

The formation of secondary structures by a random RNA sequence is studied as a model system for the sequence-structure problem omnipresent in biopolymers. Several toy energy models are introduced to allow detailed analytical and numerical…

统计力学 · 物理学 2009-11-07 R. Bundschuh , T. Hwa

We discuss the physics of RNA as described by its secondary structure. We examine the static properties of a homogeneous RNA-model that includes pairing and base stacking energies as well as entropic costs for internal loops. For large…

统计力学 · 物理学 2009-11-07 M. Mueller

Formation of RNA secondary structures is an example of the sequence-structure problem omnipresent in biopolymers. A theoretical question of recent interest is whether a random RNA sequence undergoes a finite temperature glass transition. We…

统计力学 · 物理学 2007-05-23 R. Bundschuh , T. Hwa

RNA forms elaborate secondary structures through intramolecular base pairing. These structures perform critical biological functions within each cell. Due to the availability of a polynomial algorithm to calculate the partition function…

生物大分子 · 定量生物学 2019-03-04 William D. Baez , Kay Jörg Wiese , Ralf Bundschuh

The ensemble of RNA secondary structures of uniform sequences is studied analytically. We calculate the partition function for very long sequences and discuss how the cross-over length, beyond which asymptotic scaling laws apply, depends on…

生物物理 · 物理学 2007-05-23 Tsunglin Liu , Ralf Bundschuh

We study the force-induced unfolding of random disordered RNA or single-stranded DNA polymers. The system undergoes a second order phase transition from a collapsed globular phase at low forces to an extensive necklace phase with a…

软凝聚态物质 · 物理学 2009-11-07 M. Mueller , F. Krzakala , M. Mezard

We propose a dynamical model for the secondary structure of DNA, which is based on the finite stacking enthalpies used in thermodynamics calculations. In this model, the two strands can separate and the bases are allowed to rotate…

生物物理 · 物理学 2016-08-16 Sahin Buyukdagli , Michaël Sanrey , Marc Joyeux

Folding of RNA is subject to a competition between entropy, relevant at high temperatures, and the random, or random looking, sequence, determining the low- temperature phase. It is known from numerical simulations that for random as well…

生物大分子 · 定量生物学 2015-05-13 Francois David , Kay Joerg Wiese

We examine the behavior of a model which describes the melting of double-stranded DNA chains. The model, with displacement-dependent stiffness constants and a Morse on-site potential, is analyzed numerically; depending on the stiffness…

统计力学 · 物理学 2009-10-31 Nikos Theodorakopoulos , Thierry Dauxois , Michel Peyrard

We describe a novel method which allows the treatment of high orders of replica-symmetry-breaking (RSB) at low temperatures as well as at T=0 directly, without a need for approximations or scaling assumptions. It yields the low temperature…

无序系统与神经网络 · 物理学 2013-05-29 Manuel J. Schmidt , Reinhold Oppermann

Considering marginally relevant and relevant deformations of the weakly coupled $(3+1)$-dimensional large $N$ conformal gauge theories introduced in arXiv:2011.13981, we study the patterns of phase transitions in these systems that lead to…

高能物理 - 理论 · 物理学 2021-09-15 Soumyadeep Chaudhuri , Eliezer Rabinovici

RNA's diversity of structures and functions impacts all life forms since primordia. We use calorimetric force spectroscopy to investigate RNA folding landscapes in previously unexplored low-temperature conditions. We find that Watson-Crick…

生物大分子 · 定量生物学 2024-04-30 Paolo Rissone , Aurelien Severino , Isabel Pastor , Felix Ritort

The order parameter P(q) for disordered systems with degenerate ground-states is reconsidered. We propose that entropy fluctuations lead to a trivial P(q) at zero temperature as in the non-degenerate case, even if there are zero-energy…

统计力学 · 物理学 2009-10-31 F. Krzakala , O. C. Martin

We study the localization in the one-dimensional trap model in terms of statistical mechanics of trajectories. By numerically investigating overlap between trajectories of two particles on a common disordered potential, we find that there…

统计力学 · 物理学 2017-03-14 Masahiko Ueda , Shin-ichi Sasa

A linear external perturbation is introduced in the action of the partition function of the random matrix model of RNA [G. Vernizzi, H. Orland and A. Zee, Phys. Rev. Lett. 94, 168103 (2005)]. It is seen that (i). the perturbation…

生物大分子 · 定量生物学 2009-11-20 I. Garg , N. Deo

We study the dynamics of a particle in a one-dimensional Gaussian random potential with logarithmic correlations. It was shown in previous studies that the model exhibits a dynamical transition between two subdiffusive phases. We…

统计力学 · 物理学 2018-05-17 Masahiko Ueda
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