相关论文: Network-Based Interventions for HIV Prevention via…

A central challenge in Human Immunodeficiency Virus (HIV) public health policy lies in determining whether to universally expand treatment access, despite the risk of sub-optimal adherence and consequent drug resistance, or to adopt a more…

This study utilizes mathematical models to assess progress toward achieving the UNAIDS 90-90-90 and 95-95-95 targets aimed at managing and eradicating HIV/AIDS. It contrasts stochastic and deterministic models, focusing on their utility in…

Background: Highly effective direct-acting antiviral (DAA) regimens (90% efficacy) are becoming available for hepatitis C virus (HCV) treatment. This therapeutic revolution leads us to consider possibility of eradicating the virus. However,…

Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV infected people were receiving antiretroviral therapy in low-income and middle-income countries.…

Random mixing in host populations has been a convenient simplifying assumption in the study of epidemics, but neglects important differences in contact rates within and between population groups. For HIV/AIDS, the assumption of random…

We consider a network where an infection cascade has taken place and a subset of infected nodes has been partially observed. Our goal is to reconstruct the underlying cascade that is likely to have generated these observations. We reduce…

Efficient allocation of limited medical resources is crucial for controlling epidemic spreading on networks. Based on the susceptible-infected-susceptible model, we solve an optimization problem as how best to allocate the limited resources…

The development of potent drugs for the control of viraemia in people living with HIV means that infected people may live a normal, healthy life and offers the prospect of eliminating HIV transmission in the short term and HIV infection in…

Men who have sex with men (MSM) remain disproportionately affected by HIV, yet optimizing Pre-exposure Prophylaxis (PrEP) distribution remains a public health challenge. Current guidelines and most modelling studies do not incorporate…

In this paper, we construct a model to describe the transmission of HIV in a homogeneous host population. By considering the specific mechanism of HIV, we derive a model structured in three successive stages: (i) primary infection, (ii)…

The extent to which ART (anti-retroviral therapy) reduces HIV transmission has received attention in recent years. Using data on the relationship between transmission and viral load we show that transmission saturates at high viral loads.…

Evaluating causal effects in the presence of interference is challenging in network-based studies of hard-to-reach populations. Like many such populations, people who inject drugs (PWID) are embedded in social networks and often exert…

This paper revisits a longstanding problem of interest concerning the distributed control of an epidemic process on human contact networks. Due to the stochastic nature and combinatorial complexity of the problem, finding optimal policies…

The outbreak of a pandemic, such as COVID-19, causes major health crises worldwide. Typical measures to contain the rapid spread usually include effective vaccination and strict interventions (Nature Human Behaviour, 2021). Motivated by…

Human immunodeficiency virus (HIV) is a major public health concern in the United States (U.S.), with about 1.2 million people living with it and about 35,000 newly infected each year. There are considerable geographical disparities in HIV…

Influence maximization in networks is a central problem in machine learning and causal inference, where an intervention on a subset of individuals triggers a diffusion process through the network. Existing approaches typically optimize…

HIV is a deadly virus transmitted either through having of unprotected sex, mother to child transmission, sharing of unsterilized objects that is capable of making cut or wounds on the body, through blood or bodily fluid transmission. AIDS…

Vaccination has played an important role in preventing the spread of infectious diseases. However, the limited availability of vaccines and personnel at the roll-out of a new vaccine and the costs of vaccination campaigns often limit how…

Deployment of anti-virus software is a common strategy for preventing and controlling the propagation of computer viruses and worms over a computer network. As the deployment of such programs is often limited due to monetary or operational…

Hepatitis C virus (HCV) infection is endemic in people who inject drugs (PWID), with prevalence estimates above 60 percent for PWID in the United States. Previous modeling studies suggest that direct acting antiviral (DAA) treatment can…